Video vs. Direct Laryngoscopy for Less Invasive Surfactant Administration
Randomized Controlled Trial of Video-Laryngoscopy Intervention or Direct Laryngoscopy for Delivery of Less Invasive Surfactant Administration for Premature Infants
University of Texas Southwestern Medical Center
100 participants
Jun 11, 2026
INTERVENTIONAL
Conditions
Summary
Many preterm babies born between 22-28+6 weeks' estimated gestational age (EGA) need surfactant, a medicine that helps the lungs. The goal of the study is to compare the use of video-based visualization to direct visualization during a procedure called less invasive surfactant administration (LISA). The main questions the study aims to answer are: 1) does one method of visualization have a increased rate of giving the medicine successfully on the first attempt? 2) what benefits are there of each method?
Eligibility
Inclusion Criteria1
- Infants born ≤28 weeks GA successfully resuscitated in the delivery room (DR) and maintained on CPAP • Need for surfactant in the first 36 hours of life based on clinical assessment and/or meeting threshold per unit protocol
Exclusion Criteria4
- Infants born ≥29 weeks GA or
- Infants with known congenital anomalies or
- Infants who are determined by the primary care team to receive comfort care only or
- Infants who are intubated at any time prior to surfactant administration
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Interventions
Video Laryngoscopy will be used to visualize the vocal cords and place the LISA catheter
Direct Laryngoscopy will be used to visualize the vocal cords and place the LISA catheter
Locations(1)
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NCT07426016