Rehab and Mechanical Ventilation
Rehabilitation-based Approaches to Prevent Mechanical Ventilation-induced Breathing Dysfunction
University of Florida
16 participants
Mar 30, 2026
INTERVENTIONAL
Conditions
Summary
The goal of this research study is to evaluate the effects of a single session of rehabilitation in healthy adults, before noninvasive mechanical ventilation (MV). MV can help support breathing function during sleep or illness. High levels of MV support have been reported to alter the function of the diaphragm muscle, the primary breathing muscle, in people with compromised health. However, rehabilitation may have some potential to improve diaphragm function in advance of using MV. This study will test different rehabilitation interventions, including (1) inspiratory strength training (IST), (2) transcutaneous spinal cord stimulation (TSCS), or sham TSCS. Before and after MV, participants will complete breathing strength tests and responses to phrenic nerve stimulation.
Eligibility
Inclusion Criteria1
- Non-smokers Sedentary or recreationally active Normal lung function No history of claustrophobia
Exclusion Criteria1
- Current smoking or vaping Obstructive lung disease Use of antibiotics or systemic corticosteroids to treat an acute condition History of sepsis or metastatic disease Post infectious conditions that affect breathing Diagnosed with a neurological or neuromuscular condition Any use of supplemental oxygen, continuous positive airway pressure (CPAP), or other positive pressure ventilation to treat sleep apnea Cardiac disease Orthopedic conditions that impair lung expansion Pregnancy Implanted metallic devices within 10 cm of the cervical spine
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Interventions
Transcutaneous spinal cord stimulation at 2mA intensity, for 20 minutes.
5 sets of 5 breaths of high-intensity inspiratory strength training
Transcutaneous spinal cord stimulation at reduced intensity, lasting 1 minute at the beginning and end of a 20-minute session.
Locations(1)
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NCT07427121