Rehab and Mechanical Ventilation
Rehabilitation-based Approaches to Prevent Mechanical Ventilation-induced Breathing Dysfunction
University of Florida
16 participants
Mar 30, 2026
INTERVENTIONAL
Conditions
Summary
The goal of this research study is to evaluate the effects of a single session of rehabilitation in healthy adults, before noninvasive mechanical ventilation (MV). MV can help support breathing function during sleep or illness. High levels of MV support have been reported to alter the function of the diaphragm muscle, the primary breathing muscle, in people with compromised health. However, rehabilitation may have some potential to improve diaphragm function in advance of using MV. This study will test different rehabilitation interventions, including (1) inspiratory strength training (IST), (2) transcutaneous spinal cord stimulation (TSCS), or sham TSCS. Before and after MV, participants will complete breathing strength tests and responses to phrenic nerve stimulation.
Eligibility
Plain Language Summary
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Interventions
Transcutaneous spinal cord stimulation at 2mA intensity, for 20 minutes.
5 sets of 5 breaths of high-intensity inspiratory strength training
Transcutaneous spinal cord stimulation at reduced intensity, lasting 1 minute at the beginning and end of a 20-minute session.
Locations(1)
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NCT07427121