Nicotinamide Adenine Dinucleotide Responses to a Nutritional Supplement

Exclusion Criteria25

• Is currently following, or planning to be on, a weight loss regimen.
• Weight loss or gain \>4.5 kg.
• History of gastrointestinal surgery for weight reducing purposes.
• History of an eating disorder (e.g., anorexia nervosa or bulimia nervosa, binge eating) at the discretion of the Clinical Investigator.
• History of neurologic disorder that could produce cognitive deterioration.
• History of bouts of delirium, confusion, repeated minor head injury or a single injury.
• History of unconventional sleep patterns or a diagnosed sleep disorder.
• History of any infective or inflammatory brain disease.
• Use of tobacco/nicotine products.
• Use of hemp/marijuana products.
• Unstable use of any prescription medication.
• Unstable use (initiation or change in dose) of hormonal contraceptives or therapy.
• Use of any dietary supplements (orally or infused), other than a conventional once daily multi-vitamin.
• Use of medication(s) or dietary supplement(s) known to affect absorption.
• Recent history of or strong potential for alcohol or substance abuse.
• Exposed to any non-registered drug product.
• A score of \<7 on the Vein Access Scale Assessment.
• History or presence, on the basis of the medical history or screening labs, of clinically important cardiac, renal, hepatic, endocrine (including diabetes mellitus), pulmonary, gastrointestinal, biliary, pancreatic, or neurological disorders.
• Uncontrolled hypertension.
• Known allergy to any ingredients contained in the study product.
• Any signs or symptoms of active infection of clinical relevance.
• History or presence of cancer in the prior 2 years, except for non-melanoma skin cancer.
• History of any major trauma or major surgical event.
• Female who is pregnant, planning to be pregnant during the study period, lactating, or is of childbearing potential with unstable use of sex hormones for contraception.
• An employee or representative who has a financial interest in Sponsor organization.