RecruitingNot ApplicableNCT07428967

AV Node Ablation and CONDUCTion System Pacing for Atrial Fibrillation With Preserved Left Ventricular Function

AtrioVentricular Node Ablation and CONDUCTion System Pacing for Atrial Fibrillation With Preserved Left Ventricular Function - a Randomized Controlled Trial

Sponsor

St. Josefs-Hospital Wiesbaden GmbH

Enrollment

86 participants

Start Date

Feb 1, 2026

Study Type

INTERVENTIONAL

Conditions

Atrial Fibrillation Atrial Arrhythmia

Summary

AVA CONDUCT is a prospective, multicenter, randomized study with single blinding, comparing left bundle branch area (LBBA) pacing with right ventricular (RV) pacing following AV node ablation in terms of clinical, functional, and electrophysiological outcomes. The primary hypothesis is that pacing-induced cardiomyopathy, defined as a decrease in LVEF by 10% or more from baseline to an absolute value below 50%, occurs significantly more frequently in patients receiving RV pacing compared with LBBA pacing. Secondarily, LBBA pacing is expected to maintain comparable procedural safety while providing better cardiac function, resulting in improved quality of life and functional capacity compared with conventional RV pacing.

Eligibility

Min Age: 18 Years

Plain Language Summary

Simplified for easier understanding

This study is comparing two types of pacemaker implantation after a procedure called AV node ablation for people with atrial fibrillation (an irregular heart rhythm) that has not been adequately controlled by medication or other procedures. The two pacemaker types are a traditional right ventricular pacemaker and a newer conduction system pacemaker that more closely mimics natural heart electrical activity. **You may be eligible if...** - You are 18 years old or older - You have symptomatic atrial fibrillation that has not been adequately managed - Your heart's pumping function is preserved (ejection fraction 50% or above) - You are already scheduled for AV node ablation as part of your care **You may NOT be eligible if...** - Your heart pumping function is impaired (ejection fraction below 50%) - You already have a pacemaker implanted - You have severe heart valve disease - You have had coronary bypass surgery within 30 days - You are pregnant, have a BMI over 40, or have a life expectancy under 12 months Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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