RecruitingNot ApplicableNCT07428967

AV Node Ablation and CONDUCTion System Pacing for Atrial Fibrillation With Preserved Left Ventricular Function

AtrioVentricular Node Ablation and CONDUCTion System Pacing for Atrial Fibrillation With Preserved Left Ventricular Function - a Randomized Controlled Trial

Sponsor

St. Josefs-Hospital Wiesbaden GmbH

Enrollment

86 participants

Start Date

Feb 1, 2026

Study Type

INTERVENTIONAL

Conditions

Atrial Fibrillation Atrial Arrhythmia

Summary

AVA CONDUCT is a prospective, multicenter, randomized study with single blinding, comparing left bundle branch area (LBBA) pacing with right ventricular (RV) pacing following AV node ablation in terms of clinical, functional, and electrophysiological outcomes. The primary hypothesis is that pacing-induced cardiomyopathy, defined as a decrease in LVEF by 10% or more from baseline to an absolute value below 50%, occurs significantly more frequently in patients receiving RV pacing compared with LBBA pacing. Secondarily, LBBA pacing is expected to maintain comparable procedural safety while providing better cardiac function, resulting in improved quality of life and functional capacity compared with conventional RV pacing.

Eligibility

Min Age: 18 Years

Inclusion Criteria5

History of symptomatic AF (EHRA IIb - IV) despite guideline-indicated medical or interventional therapy
Preserved LVEF (≥ 50%, assessed by echocardiography, Simpson's biplane method)
AV node ablation scheduled independently of possible study participation
Age ≥ 18 years
Consent capacity

Exclusion Criteria9

Impaired LVEF (\< 50%)
Pre-implanted pacemaker
Contraindication for pacemaker implantation or AV node ablation (see chapter 5.3 for details)
High grade (III°) left cardiac valvular disease
Surgical coronary revascularization (within the last 30 days) or current triple therapy after stent PCI
Body-mass-index \> 40 kg/m2
Pregnancy
Inability to give written informed consent
Life expectancy \< 12 months