RecruitingNot ApplicableNCT07429305

Combined Tibial Nerve Stimulation and Standing for People With SCI

Changes in Pelvic Floor Function With Tibial Neuromodulation Combined With Standing Therapy

Sponsor

University of British Columbia

Enrollment

12 participants

Start Date

Apr 2, 2026

Study Type

INTERVENTIONAL

Conditions

Spinal Cord Injury

Summary

The goal of this clinical trial is to understand how sensory inputs from the lower leg can influence pelvic floor muscle function and urogential function in adults with chronic spinal cord injury (SCI). The main questions it aims to answer are: 1. What is the modulatory role of load and posture on reflex activation of the pelvic floor muscles in participants with SCI? 2. What is the feasibility of combining tibial neuromodulation with standing therapy in participants with SCI? 3. What are the potential effects of combined tibial neuromodulation and standing therapy on reflex excitability and urogential symptoms and quality of life in people with SCI? Participants will be asked complete a series of assessments (questionnaires, electrophysiological testing) before and after a 12-week intervention of combined standing and tibial nerve stimulation therapy.

Eligibility

Min Age: 19 Years

Inclusion Criteria6

At least 19 years of age
Have a SCI between C7 - T10 that occurred at least 12 months previously
Have a motor-complete or incomplete SCI (AIS A, B, C, or D)
Have symptoms of neurogenic LUT dysfunction
Meet the manufacture requirements for standing frame use (will be evaluated by the research team)
Are able to speak and understand English.

Exclusion Criteria10

Have changed their bladder management program in the past month
Have received an injection of Botulinum toxin-A in any LUT structure in the past 2 weeks, or intend to receive an injection while participating in the trial
Have a non-stable SCI (e.g. spinal tumor)
Have signs of a lower motoneuron injury (e.g. cauda equina syndrome)
Have other neurological injury besides SCI
Have an implanted metallic or electronic device (e.g. pace maker, nerve stimulator)
Have a condition for which exercise or transcutaneous stimulation is contraindicated
Have a severe acute medical issue that in the investigator's judgement would adversely affect the participant's participation in the study. Examples include, but are not limited to acute urinary tract infections, pressure sores, musculoskeletal injury, or unmanage blood pressure.
Are currently pregnant or have given birth within the past 12 months
Use walking as your primary means of movement around your home and the community.