Precision Medicine Approaches for Neoadjuvant Therapy in High-risk Sarcoma Patients

This study develops personalised (precision medicine) treatment plans for people with high-risk soft tissue sarcoma — a type of cancer that forms in muscles, fat, or connective tissue — using tumour biopsies to guide pre-surgery treatment choices. **You may be eligible if...** - You have been diagnosed with a high-risk soft tissue sarcoma (specifically: dedifferentiated liposarcoma, leiomyosarcoma, synovial sarcoma, vascular sarcomas, or malignant peripheral nerve sheath tumour, or other subtypes with investigator approval) - Your tumour is larger than 5 cm, grade 3, or in a deep location - Your tumour can be safely biopsied - You have provided written consent **You may NOT be eligible if...** - Your tumour cannot be safely biopsied - You have a sarcoma subtype not covered by the study - You have significant health conditions that prevent surgery or chemotherapy Talk to your doctor to see if this trial is right for you.