Prefrontal Neuroplasticity and Coping Strategies in Healthy Population
Prefrontal Neuroplasticity and Coping Strategies in Healthy Population: a Randomized Sham Controlled Trial
The Hong Kong Polytechnic University
42 participants
Jan 17, 2026
INTERVENTIONAL
Conditions
Summary
The current study serves as a pilot for the GRF project "Predicting illness trajectories in fully remitted major depression using concurrent TBS/fNIRS." The project examines whether intermittent theta-burst stimulation (iTBS) induces immediate changes in prefrontal excitability in healthy individuals, compared to sham stimulation. In this randomized, sham-controlled trial, investigators will assess several psychological measures-including the Perceived Stress Scale and the Coping Inventory for Stressful Situations-to explore how stress levels and coping strategies relate to immediate prefrontal cortex (PFC) activity changes following TBS.
Eligibility
Inclusion Criteria1
- years old;
Exclusion Criteria5
- a family history of psychiatric disorders;
- history of or currently diagnosed neuropsychiatric conditions;
- history of or active systemic illnesses such as cancer, epilepsy, diabetes, hypertension, or other medical conditions;
- contraindications to transcranial magnetic stimulation (TMS);
- any prior exposure to brain stimulation procedures.
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Interventions
sham stimulation protocols is to mimic the sensations experienced by participants during active stimulation, without stimulating the brain
Locations(1)
View Full Details on ClinicalTrials.gov
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NCT07433829