RecruitingEarly Phase 1NCT07434115

Orthobiological Therapies in Musculoskeletal Disorders

Clinical and Functional Evaluation of Orthobiological Therapies in Musculoskeletal Conditions


Sponsor

PROREGEN

Enrollment

300 participants

Start Date

Sep 16, 2026

Study Type

INTERVENTIONAL

Conditions

Summary

To evaluate the clinical and functional effects of using orthobiological therapies (hyaluronic acid, platelet-rich plasma, bone marrow aspirate, nanofat, among others) in the treatment of various musculoskeletal diseases in patients routinely treated at the Proregen Medical Clinic and its affiliates. The sample will consist of adult patients (≥18 years), of both sexes, with different musculoskeletal diagnoses involving joints, tendons, ligaments, cartilage or bone, among others.


Eligibility

Min Age: 18 Years

Plain Language Summary

Simplified for easier understanding

This clinical trial is studying a biological treatment called Bone Marrow Concentrate (BMAC), a biological treatment called Hyaluronic Acid (Viscosupplementation), and others for people with musculoskeletal diseases or conditions. The study is currently recruiting participants at 1 location.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

BIOLOGICALPRP injection

Obtained by centrifuging blood, it concentrates platelets and growth factors for regeneration.

BIOLOGICALBone Marrow Concentrate (BMAC)

Bone marrow aspirate, rich in mesenchymal stem cells and progenitor cells for tissue repair.

BIOLOGICALHyaluronic Acid (Viscosupplementation)

Used for joint lubrication and cartilage protection, very common in osteoarthritis.

BIOLOGICALNanofat

It is an even more refined and liquefied form of processed fat, used primarily for high-precision tissue repair.


Locations(1)

Clínica Proregen | Clínica Ortopédica em Bento | Dr. André Kruel

Bento Gonçalves, Rio Grande do Sul, Brazil

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NCT07434115


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