RecruitingNCT07434518

A Real-World Study Evaluating the Efficacy and Safety of Adebrelimab in Patients With Advanced SCLC

A Real-world Study on the Efficacy and Safety of Adebrelimab in the Treatment of Advanced-stage Small Cell Lung Cancer


Sponsor

Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine

Enrollment

500 participants

Start Date

Jan 27, 2026

Study Type

OBSERVATIONAL

Conditions

Summary

The goal of this observational study is to evaluate the safety and efficacy of adebrelimab in the perioperative and advanced-stage treatment of small cell lung cancer (SCLC) under real-world conditions. The main questions it aims to answer are: 1. The safety of adebrelimab treatment in patients with advanced SCLC under real-world conditions, with a specific focus on the incidence of grade ≥3 immune-related adverse events. Safety monitoring begins when patients start receiving adebrelimab treatment and continues until 90 days after the last dose of adebrelimab. 2. Observe and evaluate the efficacy of adebrelimab in patients with small cell lung cancer under real-world conditions. This includes overall survival (OS), progression-free survival (PFS), objective response rate (ORR), and disease control rate (DCR). Additionally, the study seeks to further explore the impact of patient baseline characteristics, such as brain metastases or liver metastases, and biomarkers on prognosis.


Eligibility

Min Age: 18 YearsMax Age: 100 Years

Plain Language Summary

Simplified for easier understanding

This real-world study evaluates how well adebrelimab (an immunotherapy drug) works and how safe it is in people with extensive-stage small cell lung cancer (SCLC) — an aggressive type of lung cancer — in everyday clinical practice outside of a controlled trial setting. **You may be eligible if...** - You have extensive-stage small cell lung cancer confirmed by biopsy or laboratory testing - You are 18 or older - Your doctor has determined that adebrelimab is an appropriate treatment for you, or you are already receiving it **You may NOT be eligible if...** - You are currently receiving other immune-modifying drugs or treatments that could interfere with adebrelimab - You are already enrolled in another interventional clinical trial Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

BIOLOGICALAdebrelimab (PD-L1 inhibitor)

Investigating the efficacy and long-term safety of adebrelimab in different subgroups of SCLC patients (e.g., elderly patients, patients with comorbidities) in a real-world setting.


Locations(1)

Shanghai General Hospital

Shanghai, China

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NCT07434518


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