RecruitingNot ApplicableNCT07437417

A Novel Volume Stable Matrix for Gingival Recession Coverage at Teeth

Assessment of Connective Tissue Graft vs. a New Collagen Matrix for Periodontal Tissue Thickening and Coverage of Single or Multiple Adjacent Gingival Recessions of Orthodontically Treated Patients. A Randomized Clinical Trial


Sponsor

University of Bern

Enrollment

60 participants

Start Date

Sep 1, 2025

Study Type

INTERVENTIONAL

Conditions

Summary

Periodontal health and preservation of the dentition without tooth loss are important quality of life components and should be safeguarded in order to provide optimal function and esthetics. Optimal treatment of gingiva recessions is likely to allow for more efficient use of healthcare resources and reduced costs long-term. It is evident that the prevalence in gingival recession is high and its consequences on the aging population constitute an important healthcare issue that requires further attention. The standard therapy of gingival recession encompasses a coronally advanced flap or coronally advanced tunnel flap and a connective tissue graft from the palate. Harvesting of the palatal graft involves a second surgical site and increased morbidity for the patients.This project aims to compare the connective tissue graft against a novel volume stable collagen matrix. Patients will be treated according to standard protocols of the Department of Periodontology. In the test group patient will undergo tissue thickening with a collagen matrix and the modified coronally advanced tunnel technique. The control group will undergo the standard protocol using a connective tissue graft from the palate along with the modified coronally advanced tunnel technique. No study specific risks do exist.


Eligibility

Min Age: 18 Years

Inclusion Criteria3

  • Written informed consent
  • Healthy patients referred to the clinic for recession coverage
  • Miller Class I, II or III facial gingival recession (GR) defect, \>3 mm, located on the buccal of the maxillary or mandibular canine and incisor area.

Exclusion Criteria1

  • History of diseases with hypocoagulability, instable diabetes mellitus, post-irradiation in the head and neck area, infectious diseases or heart diseases that need prophylactic antibiosis before dental treatments or a medication with effect on the gingiva: Ciclosporin A, compounds of Phenytoin, calcium channel blockers, pregnant or breastfeeding patients

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Interventions

PROCEDUREVolume stable collagen matrix

The volume stable collagen matrix will be used together with the modified coronally advanced tunnel technique to cover the gingival recession defect.

PROCEDUREControl

A connective tissue harvested from the palate will be used for tissue augmentation together with the modified coronally advanced tunnel technique to cover the gingival recession defect.


Locations(1)

Department of Periodontology

Bern, Switzerland

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NCT07437417


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