RecruitingPhase 2Phase 3NCT07440225

A Clinical Trial of EYE201/MK-8748 in People With Macular Degeneration (MK-8748-002)

A Randomized Double-masked, Multicenter, 3-arm, Pivotal Phase 2/3 Study to Evaluate the Efficacy and Safety of Intravitreal (IVT) EYE201/MK-8748 Compared to Aflibercept (2 mg) in Participants With Neovascular Age-related Macular Degeneration (NVAMD)

Sponsor

EyeBiotech Ltd.

Enrollment

960 participants

Start Date

Mar 27, 2026

Study Type

INTERVENTIONAL

Conditions

Summary

Researchers are looking for new ways to treat neovascular age-related macular degeneration (NVAMD). Available standard (usual) treatments for NVAMD, such as aflibercept, may not work for every person. Researchers want to learn if a trial medicine called tiespectus (also called MK-8748 or EYE201) can treat NVAMD. The goal of this trial is to learn if tiespectus works as well as aflibercept to treat NVAMD.

Eligibility

Min Age: 50 Years

Plain Language Summary

Simplified for easier understanding

This clinical trial is studying a drug called Aflibercept and a drug called Tiespectus for people with age-related macular degeneration, choroidal neovascularization, and other related conditions. The study is currently recruiting participants at 97 locations.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

DRUGTiespectus

Administered by intravitreal (IVT) injection

DRUGAflibercept

Administered by intravitreal injection (IVT)

Locations(124)

Research Network Arizona / Retina Macula Institute of Arizona

Scottsdale, Arizona, United States

Retina Center of Arkansas

Fayetteville, Arkansas, United States

Retina Partners of Northwest Arkansas, PLLC

Springdale, Arkansas, United States

Global Research Management, Inc.

Glendale, California, United States

Retinal Consultants Medical Group (Site 024)

Modesto, California, United States

Azul Vision / California Eye Specialists Medical Group, Inc.

Pasadena, California, United States

Retina Consultants of Southern California (Site 043)

Redlands, California, United States

Retinal Consultants Medical Group (Site 020)

Sacramento, California, United States

Retinal Consultants Medical Group (Site 022)

Sacramento, California, United States

Florida Eye Clinic (Site 130)

Altamonte Springs, Florida, United States

Retina Group of Florida (Site 070)

Fort Lauderdale, Florida, United States

Vitreo Retinal Associates

Gainesville, Florida, United States

Florida Retina Institute

Jacksonville, Florida, United States

Florida Retina Consultants

Lakeland, Florida, United States

Retina Care Specialists

Palm Beach Gardens, Florida, United States

Fort Lauderdale Eye Institute (Site 042)

Plantation, Florida, United States

Retina Vitreous Associates of Florida (Site 049)

St. Petersburg, Florida, United States

Southern Vitreoretinal Associates

Tallahassee, Florida, United States

Retina Associates of Florida, LLC

Tampa, Florida, United States

Retina Vitreous Associates of Florida

Tampa, Florida, United States

Wildwood Clinical Research / Florida Retina Institute

Wildwood, Florida, United States

Illinois Retina Associates

Oak Park, Illinois, United States

Springfield Clinic

Springfield, Illinois, United States

Associated Vitreoretinal and Uveitis Consultants

Carmel, Indiana, United States

Midwest Eye Institute

Carmel, Indiana, United States

Cumberland Valley Retina Consultants (Site 007)

Hagerstown, Maryland, United States

Foundation for Vision Research (Site 073)

Grand Rapids, Michigan, United States

Retina Consultants of Minnesota

Saint Louis Park, Minnesota, United States

Retina Specialists of Mississippi

Hattiesburg, Mississippi, United States

Mississippi Retina Associates (Site 084)

Madison, Mississippi, United States

Mid Atlantic Retina

Cherry Hill, New Jersey, United States

Vision Research Center Eye Associates of New Mexico

Albuquerque, New Mexico, United States

ong Island Vitreoretinal Consultants / Vitreoretinal Consultants of NY (Site 105)

Hauppauge, New York, United States

Retina Vitreous Surgeons of CNY, PC (Site 033)

Liverpool, New York, United States

Piedmont Retina Specialists - Greensboro

Greensboro, North Carolina, United States

North Carolina Retina Associates

Greenville, North Carolina, United States

Piedmont Retina Specialists - Winston-Salem

Winston-Salem, North Carolina, United States

Cincinnati Eye Institute (Site 133)

Cincinnati, Ohio, United States

Retina Vitreous Center

Edmond, Oklahoma, United States

Tulsa Retina Consultants

Tulsa, Oklahoma, United States

Retina Northwest, PC

Portland, Oregon, United States

EyeHealth Northwest

Portland, Oregon, United States

Mid Atlantic Retina (Site 050)

Bethlehem, Pennsylvania, United States

Palmetto Retina Center

Aiken, South Carolina, United States

Charleston Neuroscience Institute - Bluffton (Site 124)

Bluffton, South Carolina, United States

Charleston Neuroscience Institute (Site 104)

Charleston, South Carolina, United States

Charleston Neuroscience Institute (CNI) d/b/a Retina Consultants of South Carolina

Mt. Pleasant, South Carolina, United States

Charles Retina Institute

Germantown, Tennessee, United States

Retina Research Institute of Texas (Site 010)

Abilene, Texas, United States

Southwest Retina Specialists

Amarillo, Texas, United States

Texas Retina Associates

Arlington, Texas, United States

Austin Research Center for Retina

Austin, Texas, United States

Austin Retina Associates (Site 012)

Austin, Texas, United States

Retina & Vitreous of Texas

Bellaire, Texas, United States

Texas Retina Associates

Dallas, Texas, United States

Texas Retina (Site 037)

Plano, Texas, United States

Retina Center of Texas

Southlake, Texas, United States

Retina Consultants of Texas (Site 014)

The Woodlands, Texas, United States

Tyler Retina Research Institute

Tyler, Texas, United States

Strategic Clinical Research Group

Weatherford, Texas, United States

Retina Associates of Utah

Salt Lake City, Utah, United States

Piedmont Eye Center (Site 054)

Lynchburg, Virginia, United States

Pacific Northwest Retina (Site 112)

Burlington, Washington, United States

Spokane Eye Clinical Research (Site 075)

Spokane, Washington, United States

Retina Consultants, PLLC

Charleston, West Virginia, United States

Eye Clinic of Wisconsin

Wausau, Wisconsin, United States

Grupo Laser Vision (Rosario Eximer Laser Vision SA)

Rosario, Santa Fe Province, Argentina

Oftalmología Global (Centro Médico Oftalmología Global) (Site 304)

Rosario, Santa Fe Province, Argentina

Microcirugia Ocular Rosario (Site 310)

Rosario, Santa Fe Province, Argentina

Centro de Ojos Quilmes

Buenos Aires, Argentina

Clinica Privada de Ojos

Buenos Aires, Argentina

Fundacion Jorge Zambrano para la investigación, diagnostivo y tratamiento de enfermedades oculares (Site 302)

Buenos Aires, Argentina

RSresearch (Site 308)

Buenos Aires, Argentina

Instituto Oftalmologico de Buenos Aires SA (Site 306)

Buenos Aires, Argentina

Centro Oftalmologico Dr Charles y Asociados (Site 300)

Buenos Aires, Argentina

Centro de Ojos Loria SRL (Site 312)

Buenos Aires, Argentina

Centro Oftalmológico Dr. Zas

Buenos Aires, Argentina

Hospital Britanico- Microcentro

Cdad. Autónoma de Buenos Aires, Argentina

Instituto Donato

Cdad. Autónoma de Buenos Aires, Argentina

Instituto de Microcirugía Ocular Córdoba (IMOC S.R.L) (Site 305)

Córdoba, Argentina

Centro Privado de Ojos Romagosa SA (Site 307)

Córdoba, Argentina

Centrovision Clinica Oftalmologica

Mendoza, Argentina

Oftar Centro De Oftalmología en Mendoza

Mendoza, Argentina

Centro de la Visión (Site 309)

Salta, Argentina

Centro de la Visión

Salta, Argentina

Instituto Zeman Bardeci (Site 311)

Salta, Argentina

Eye Clinic Albury Wodonga (Site 425)

Albury, Australia

Retina and Eye Consultants

Hurstville, Australia

Launceston Eye Doctors

Launceston, Australia

Marsden Eye Specialists (Site 420)

Parramatta, Australia

Marsden Eye Specialists (Site 423)

Strathfield, Australia

Sydney Eye Hospital (Site 426)

Sydney, Australia

Sydney Retina Clinic and Day Surgery (Site 424)

Sydney, Australia

East Tallinn Central Hospital

Tallinn, Estonia

Silmalaser OÜ

Tallinn, Estonia

Tartu University Hospital

Tartu, Estonia

Universitätsklinikum Hamburg Eppendorf Klinik und Poliklinik für Augenheilkunde

Hamburg, Germany

Augenzentrum am St. Franziskus Hospital Münster

Münster, Germany

Barzilai Medical Center

Ashkelon, Israel

Rambam Health Corporation (Site 706)

Haifa, Israel

Carmel Medical Center (Site 704)

Haifa, Israel

Hadassah Medical Center Opthalmology Department (Site 701)

Jerusalem, Israel

Rabin Medical Center (Site 700)

Petah Tikva, Israel

Sheba Medical Center (Site 707)

Ramat Gan, Israel

Kaplan Medical Center Ophthalmology Department (Site 705)

Rehovot, Israel

Shamir Medical Center (Site 703)

Ẕerifin, Israel

P.Stradins clinical university hospital

Riga, Latvia

Riga East University hospital, clinical centre Bikernieki

Riga, Latvia

Northern Kurzeme Regional Hospital

Ventspils, Latvia

Oftalmika Sp. z o.o.

Bydgoszcz, Poland

Dietla Medical Center 19 Sp zoo

Krakow, Poland

Klinika okulistyczna w Olsztynie - Centrum Diagnostyki i Mikrochirurgii Oka Lens

Olsztyn, Poland

Centro Oftalmologico Metropolitano

San Juan, Puerto Rico

Clinica de Oftalmologia Barraquer

Barcelona, Spain

Hospital Universitari Vall d'Hebron - despacho de coordinación de oftalmología. Planta 8, Edifici General

Barcelona, Spain

Hospital Universitario Puerta de Hierro - Majadahonda

Madrid, Spain

University Hospital Basel, Eye Clinic

Basel, Switzerland

Swiss Eye Institute and Berner Augenklinik

Bern, Switzerland

Vista Augenklinik Binningen

Binnigen, Switzerland

Fondation Asile des aveugles (Hôpital Ophtalmique Jules-Gonin)

Lausanne, Switzerland

Stadtspital Zurich Triemli Forschungszentrum Augenklinik

Zurich, Switzerland

University Hospitals of Leicester NHS Trust (Site 209)

Leicester, United Kingdom

South West Retina

Liverpool, United Kingdom

London North West University Healthcare NHS Trust (LNWH) (Site 201)

London, United Kingdom

View Full Details on ClinicalTrials.gov

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NCT07440225

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