Umbilical Cord Mesenchymal Stem Cells as Adjuvant Therapy in Group E COPD Patients

This study is testing whether adding umbilical cord-derived stem cells to standard treatment can help people with severe, hard-to-control COPD (chronic obstructive pulmonary disease — a lung condition that makes breathing difficult). The stem cells are given as an add-on therapy to the usual inhaler combination. **You may be eligible if...** - You are between 40 and 75 years old - You have severe COPD classified as "Group E" (the most advanced category with frequent flare-ups) - You have been on a triple-inhaler therapy (a combination of three types of inhalers) for at least 6 months - Your condition has been stable for at least 2 weeks **You may NOT be eligible if...** - You are a current smoker, or quit less than 6 months ago - You had a COPD flare-up in the last 2 weeks - You have another lung condition such as tuberculosis, asthma, or lung cancer - You have HIV or another active infection - You have any type of cancer - You have severe heart, liver, or kidney disease - You are pregnant or breastfeeding - You are taking immunosuppressive medications - You have a psychiatric condition, history of alcohol or drug abuse - Your life expectancy is less than 6 months due to other illnesses Talk to your doctor to see if this trial is right for you.