RecruitingNot ApplicableNCT07444138

Effects of Beetroot Extract on Blood Pressure and Exercise in Hypertensive Older Women

Acute Effects of Beetroot Extract Supplementation on Blood Pressure, Oxidative Stress, and Muscle Oxygen Saturation in Hypertensive Older Women Submitted to an Aerobic Exercise Session

Sponsor

São Paulo State University

Enrollment

20 participants

Start Date

Oct 8, 2025

Study Type

INTERVENTIONAL

Conditions

Hypertension Hypertension (HTN)

Summary

The goal of this clinical trial is to learn about the acute effects of beetroot extract in older women with high blood pressure. The main questions it aims to answer are: Does beetroot extract affect blood pressure during exercise? Does it change oxygen levels in the muscles? Participants will take a beetroot supplement and perform an aerobic exercise session to check how their bodies respond.

Eligibility

Sex: FEMALEMin Age: 60 Years

Plain Language Summary

Simplified for easier understanding

This study is testing whether beetroot extract — which is rich in natural compounds called nitrates that can relax blood vessels — can lower blood pressure and improve exercise performance in older women with hypertension (high blood pressure). **You may be eligible if...** - You are a woman between 60 and 70 years old - You have hypertension (high blood pressure) as your primary health condition - You are physically able to complete the exercise tests required by the study **You may NOT be eligible if...** - You are a current smoker - You have a history of alcohol abuse or heavy drinking - You have been diagnosed with cardiovascular disease beyond hypertension (such as heart failure, coronary artery disease, or history of heart attack) Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

DIETARY_SUPPLEMENTBeetroot Extract (Nitrate-rich)

Participants will ingest 2 capsules of a standardized beetroot extract (Berkeley Life Nitric Oxide Foundation). Each dose provides approximately 314 mg of dietary nitrate.

DIETARY_SUPPLEMENTPlacebo

Capsules identical in appearance, color, and size to the experimental supplement, but containing an inert substance (starch). This intervention is used to maintain the double-blind design of the study.

BEHAVIORALExercise

Participants will perform a single aerobic exercise session on a treadmill. The protocol consists of a 7-minute warm-up followed by 30 minutes of continuous exercise at an intensity corresponding to 60-80% of maximum heart rate (HRmax), estimated using Tanaka's formula (208 - 0.7 \* age). Rate of Perceived Exertion (RPE) will be monitored periodically using the Borg scale (6-20).

OTHERRest (Control Condition)

Participants will remain seated for 30 minutes (matching the exercise session duration). During this time, a researcher will administer a Food Frequency Questionnaire (FFQ) in an interview format. This activity serves to assess dietary habits and simulates a routine, low-exertion daily activity (similar to a conversation), acting as a time-matched control for the exercise session.