RecruitingNCT07444879

IL-33, sST2, and CRP in Panic Disorder

Investigation of IL-33, sST2, and C-Reactive Protein in Panic Disorder: A Cross-Sectional Case-Control Study


Sponsor

Elazığ Mental Health and Diseases Hospital

Enrollment

80 participants

Start Date

Jul 7, 2025

Study Type

OBSERVATIONAL

Conditions

Summary

Panic disorder (PD) is characterized by recurrent and unexpected panic attacks and is associated with significant functional impairment. Increasing evidence suggests involvement of immune-inflammatory mechanisms in PD. Elevated levels of inflammatory markers such as C-reactive protein (CRP) have been reported in PD; however, interleukin-33 (IL-33) and soluble suppressor tumorogenicity-2 (sST2), components of the IL-33/sST2 signaling axis, have not previously been investigated in PD. This cross-sectional case-control study aims to compare peripheral serum IL-33, sST2, and CRP levels between drug-naïve subjects diagnosed with PD and healthy controls (HCs). The findings may contribute to understanding the inflammatory mechanisms underlying PD.


Eligibility

Min Age: 18 YearsMax Age: 65 Years

Plain Language Summary

Simplified for easier understanding

This study is investigating whether certain blood proteins — specifically IL-33, sST2, and CRP — are elevated in people who have panic disorder, a condition causing sudden, intense episodes of fear or physical symptoms like racing heart, shortness of breath, and dizziness. The goal is to better understand the biology behind panic disorder. **You may be eligible if:** - You are between 18 and 65 years old - You have been diagnosed with panic disorder according to current psychiatric guidelines (DSM-5-TR) - You have never taken psychiatric medication before (drug-naive) - You have no other active psychiatric conditions beyond panic disorder - You have a normal body weight range (BMI between 18.5 and 29.9) **You may NOT be eligible if:** - You have high blood pressure, diabetes, kidney failure, liver failure, or a neurological condition affecting thinking - You are currently pregnant - You have an autoimmune disease or active cancer - You have taken any medications or supplements in the past month - You have any additional psychiatric disorder Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Locations(1)

Elazığ Mental Health and Diseases Hospital Psychiatry Clinic

Elâzığ, Elâzığ, Turkey (Türkiye)

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NCT07444879


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