RecruitingNCT07446842

Construction of AI Model for Precision Imaging Diagnosis of Cranial Diseases


Sponsor

Tongji Hospital

Enrollment

1,000 participants

Start Date

Jan 1, 2026

Study Type

OBSERVATIONAL

Conditions

Summary

The goal of this observational study is to develop and validate a high-precision AI diagnostic model for cranial diseases by integrating clinical knowledge systems (pathophysiological classification, age stratification, and anatomical localization) to simulate radiologists' diagnostic thinking. The main question it aims to answer is: Does the AI model improve diagnostic accuracy and consistency across different hospital levels, physician qualifications, and clinical scenarios compared to traditional diagnosis? Participants' cranial MRI data (including T1, T2, FLAIR, DWI sequences) and clinical information will be collected retrospectively (2015-2025) and prospectively (2026) to train and validate the model, which will be evaluated through performance metrics (accuracy, sensitivity, specificity) and clinical efficacy assessments (doctor vs. model, with/without model assistance). This study will establish a new paradigm for clinical AI implementation, providing methodological support for precision diagnosis of neurological diseases.


Eligibility

Plain Language Summary

Simplified for easier understanding

This study is building an artificial intelligence (AI) model to help doctors more accurately diagnose brain diseases using imaging scans (such as MRI). Researchers are collecting brain scans from patients with 48 different brain conditions — ranging from tumors and strokes to infections and degenerative diseases — to train the AI to recognize and distinguish between them. **You may be eligible if:** - You have been clinically diagnosed with one of 48 specified brain conditions (including glioma, meningioma, stroke, multiple sclerosis, Alzheimer's disease, Parkinson's disease, brain infections, or various structural brain abnormalities) - You have complete and good-quality brain imaging data available - You are able to cooperate with the study procedures **You may NOT be eligible if:** - You have a severe neurological condition that is not one of the 48 conditions listed in the study - Your brain imaging data is incomplete or of poor quality - You have severe cognitive impairment that prevents you from understanding or participating in the study Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Locations(1)

Tongji Hospital

Wuhan, Hubei, China

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NCT07446842