RecruitingNot ApplicableNCT07446959

Minimum Effective Volume of Bupivacaine for Serratus Posterior Superior Intercostal Plane Block in Video-Assisted Thoracoscopic Surgery

Determination of the Median Effective Volume (ED50) of Bupivacaine for Serratus Posterior Superior Intercostal Plane Block in Patients Undergoing Video-Assisted Thoracoscopic Surgery Using the Dixon Up-and-Down Method

Sponsor

Bursa City Hospital

Enrollment

27 participants

Start Date

Mar 15, 2026

Study Type

INTERVENTIONAL

Conditions

Video-assisted Thoracoscopic Surgery (VATS)Postoperative Pain Management

Summary

This study aims to determine the minimum effective volume of bupivacaine required for the serratus posterior superior intercostal plane (SPSIP) block in patients undergoing video-assisted thoracoscopic surgery (VATS). The SPSIP block is an ultrasound-guided regional anesthesia technique used to provide postoperative pain relief after thoracic surgery. Using a stepwise dose-adjustment method, the volume of local anesthetic will be increased or decreased based on the effectiveness of the block in each patient. The main outcome of the study is to identify the volume that provides effective pain control in 50% of patients. The results may help optimize pain management while minimizing drug exposure.

Eligibility

Min Age: 18 Years

Inclusion Criteria5

Age 18 years or older
Scheduled for elective video-assisted thoracoscopic surgery (VATS)
American Society of Anesthesiologists (ASA) physical status I-III
Planned to receive ultrasound-guided serratus posterior superior intercostal plane block for postoperative analgesia
Ability to provide written informed consent

Exclusion Criteria8

Refusal to participate in the study
Known allergy or contraindication to local anesthetics
Infection at the block injection site
Coagulation disorders or anticoagulant therapy contraindicating regional anesthesia
Severe respiratory insufficiency
Chronic opioid use or chronic pain syndrome
Pregnancy
Inability to cooperate or communicate postoperative pain scores

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Interventions

OTHERUltrasound-Guided Serratus Posterior Superior Intercostal Plane Block

Ultrasound-guided serratus posterior superior intercostal plane block performed prior to general anesthesia in patients undergoing video-assisted thoracoscopic surgery (VATS). A 0.5% bupivacaine solution is injected, and the volume is adjusted in 2 mL increments according to the Dixon up-and-down sequential allocation method to determine the median effective volume (ED50).