RecruitingPhase 2NCT07447076

Study of Novel Therapies for Young People With Recurrent/Progressive Atypical Teratoid Rhabdoid Tumor (ATRT)

A Platform Study of Novel Therapies for Children, Adolescents and Young Adults With Recurrent/Progressive Atypical Teratoid Rhabdoid Tumor (ATRT)

Sponsor

Sabine Mueller, MD, PhD

Enrollment

29 participants

Start Date

Jun 17, 2026

Study Type

INTERVENTIONAL

Conditions

Atypical Teratoid/Rhabdoid Tumor (ATRT) of the CNS Recurrent Atypical Teratoid/Rhabdoid Tumor

Summary

This is a multi-treatment arm study that will be conducted through the Pacific Pediatric Neuro-oncology Consortium (PNOC).The study will assess the safety and efficacy of novel therapies and combinatorial strategies for participants with recurrent or progressive ATRT.

Eligibility

Min Age: 1 YearMax Age: 39 Years

Plain Language Summary

Simplified for easier understanding

This clinical trial is studying a procedure called Blood Specimen Collection, a drug called Gemcitabine, and others for people with atypical teratoid/rhabdoid tumor (atrt) of the cns and recurrent atypical teratoid/rhabdoid tumor. The study is currently recruiting participants at 2 locations. People eligible for this study include aged 1 Year to 39 Years.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

PROCEDURELumber Puncture

Cerebral Spinal Fluid (CSF) will be collected for research

PROCEDUREBlood Specimen Collection

Perform blood draw

PROCEDUREMagnetic resonance imaging (MRI)

Undergo imaging procedure

DRUGGemcitabine

Given IV

DRUGPaxalisib

Given orally (PO)

PROCEDURETumor Biopsy

Undergo biopsy

Locations(2)

University of California, San Francisco

San Francisco, California, United States

University of California, San Francisco

San Francisco, California, United States

View Full Details on ClinicalTrials.gov

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NCT07447076

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