RecruitingNot ApplicableNCT07448571

Evaluation of Revitalization Success Using i-PRF in Non-Surgical Root Canal Retreatment

Evaluation of Revitalization Success Using i-PRF in Non-Surgical Root Canal Retreatment: A Clinical Study

Sponsor

Marmara University

Enrollment

140 participants

Start Date

May 1, 2025

Study Type

INTERVENTIONAL

Conditions

Apical periodontitis periapical diseases

Summary

The goal of this randomized controlled clinical trial is to determine whether regenerative endodontic treatment can improve healing outcomes in teeth with apical periodontitis following failed root canal treatment. The study includes adult patients who require non-surgical root canal retreatment due to persistent periapical lesions. The main questions it aims to answer are: Does regenerative endodontic treatment improve periapical healing compared with conventional non-surgical root canal retreatment? Does regenerative treatment increase long-term treatment success and tooth survival? Researchers will compare conventional non-surgical root canal retreatment with regenerative endodontic treatment using injectable platelet-rich fibrin (i-PRF) to see if the regenerative approach results in better clinical and radiographic outcomes. Participants will: Be randomly assigned to receive either conventional retreatment or regenerative endodontic treatment. Undergo clinical and radiographic evaluations over a two-year follow-up period. Be assessed for pain, sensitivity, pulp vitality, hard tissue formation, and periapical healing.

Eligibility

Min Age: 18 YearsMax Age: 50 Years

Inclusion Criteria8

Patients aged between 18 and 50 years.
Single-rooted maxillary anterior teeth with closed apices.
Presence of periapical lesion confirmed radiographically.
Previously treated root canal tooth requiring non-surgical retreatment.
Tooth has not previously undergone non-surgical root canal retreatment.
Tooth is considered restorable.
Patient is systemically healthy.
Patient is willing to participate and provides informed consent.

Exclusion Criteria5

Teeth without radiographic evidence of periapical lesion.
Teeth with developmental anomalies.
Patients with systemic diseases that may affect healing.
Pregnant patients.
Teeth presenting with internal or external root resorption.

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Interventions

PROCEDURENon-Surgical Root Canal Retreatment

Conventional non-surgical root canal retreatment will be performed under local anesthesia and rubber dam isolation. Previous root canal filling materials will be removed, followed by standardized chemomechanical preparation and irrigation. The canals will be obturated using resin-based sealer and gutta-percha with lateral condensation technique, and the tooth will be restored with a permanent coronal restoration.

PROCEDURERegenerative Endodontic Treatment

Regenerative endodontic treatment will be performed under local anesthesia and rubber dam isolation. After removal of previous root canal filling materials and standardized canal preparation, injectable platelet-rich fibrin obtained from the patient's autologous blood will be applied into the canal space as a biological scaffold. Mineral trioxide aggregate will be placed coronally, followed by permanent composite restoration.