RecruitingNot ApplicableNCT07449442

SII Levels Following iPACK Block With Adductor Canal Block in Knee Arthroplasty

iPACK Block With Adductor Canal Block Mitigates Surgical Stress and Enhances Analgesia in Total Hip Arthroplasty: A Randomized Controlled Trial

Sponsor

Poznan University of Medical Sciences

Enrollment

60 participants

Start Date

Mar 1, 2026

Study Type

INTERVENTIONAL

Conditions

Knee Osteoarthritis

Summary

This randomized controlled trial evaluates the effect of ultrasound-guided iPACK block with Adductor Canal Block (ACB) on the Systemic Immune-Inflammation Index (SII) in elderly patients undergoing total hip arthroplasty under spinal anesthesia. SII, calculated as platelet × neutrophil / lymphocyte count, is used as a composite marker of perioperative inflammatory and immune response. The study investigates whether iPACK block with ACB attenuates the systemic inflammatory reaction to surgical trauma compared to sham block.

Eligibility

Min Age: 65 YearsMax Age: 100 Years

Inclusion Criteria3

Patients with ASA classification I-III
Aged 65-100 years
Who will be scheduled for hip arthroplasty under spinal anesthesia

Exclusion Criteria8

Patients who have a history of bleeding diathesis
Take anticoagulant therapy
History of chronic pain before surgery
Multiple trauma
patients unable to assess their pain (dementia)
patients operated under general anesthesia
patients having an infection in the region of the procedure
the patient who does not accept the procedure

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Interventions

DRUGsodium Chloride

After spinal anesthesia, the ultrasound-guided iPACK block will be performed with 20ml of 0.9% sodium chloride; and Adductor Canal Block will be performed with 20ml of 0.9% sodium chloride

DRUGRopivacaine Hydrocloride

After spinal anesthesia, the ultrasound-guided iPACK block will be performed with 20ml of 0.2% ropivacaine, and the Adductor Canal Block will be performed with 20ml of 0.2% ropivacaine