RecruitingPhase 3NCT07449923

CAPRI: A Phase 3 Randomized, Double-Masked Study Comparing the Efficacy of EYP-1901 Against Aflibercept in DME

A Phase 3, Multicenter, Prospective, Randomized, Double-Masked, Parallel-Group Study of EYP-1901, a Tyrosine Kinase Inhibitor (TKI), Compared to Aflibercept (2 mg) in Participants With Diabetic Macular Edema (DME)

Sponsor

EyePoint Pharmaceuticals, Inc.

Enrollment

240 participants

Start Date

Feb 9, 2026

Study Type

INTERVENTIONAL

Conditions

Diabetic Macular Edema (DME)Diabetic Macular Edema DME

Summary

This is a phase 3 randomized, double -masked study comparing the efficacy of EYP-1901 against Aflibercept.

Eligibility

Min Age: 18 Years

Plain Language Summary

Simplified for easier understanding

This clinical trial is studying a drug called Aflibercept (2.0 mg) and a drug called EYP-1901 for people with dme, diabetic macular edema, and other related conditions. The study is currently recruiting participants at 68 locations. People eligible for this study include aged 18 Years and older.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

DRUGEYP-1901

Intravitreal Injection

DRUGAflibercept (2.0 mg)

Intravitreal Injection

Locations(70)

Associated Retina Consultans

Gilbert, Arizona, United States

Associated Retina Consultants - Phoenix

Phoenix, Arizona, United States

Phoenix Retina Clinical Trials, LLC - North Phoenix

Phoenix, Arizona, United States

Retina Macula Institute of Arizona

Scottsdale, Arizona, United States

Retina Vitreous Associates Medical Group

Beverly Hills, California, United States

Retina Consultants of Orange County

Fullerton, California, United States

South Coast Retina Center

Long Beach, California, United States

Retinal Consultants Medical Group - Modesto

Modesto, California, United States

Kaiser Permanente

Oakland, California, United States

Retina Consultants of Southern California

Redlands, California, United States

Bay Area Retina Associates

Walnut Creek, California, United States

Retina Specialists of Colorado - Arvada

Arvada, Colorado, United States

Connecticut Eye Consultants, P.C.

Danbury, Connecticut, United States

Coastal Eye Surgeons, LLC

Greenwich, Connecticut, United States

Retina Group of New England, PC

Waterford, Connecticut, United States

Retina Group of Florida - Fort Lauderdale

Fort Lauderdale, Florida, United States

Retina Specialty Institute

Pensacola, Florida, United States

Fort Lauderdale Eye Institute

Plantation, Florida, United States

MedEye Associates

South Miami, Florida, United States

Retina Vitreous Associates of Florida - Saint Petersburg

St. Petersburg, Florida, United States

Retina Vitreous Associates of Florida

Tampa, Florida, United States

Retina Associates

Elmhurst, Illinois, United States

University Retina and Macula Associates

Lemont, Illinois, United States

Illinois Retina Associates, S.C.

Oak Park, Illinois, United States

Associated Vitreoretinal & Uveitis Consultants - Carmel

Carmel, Indiana, United States

The Eye Care Institute

Louisville, Kentucky, United States

Retina Associates New Orleans

Metairie, Louisiana, United States

Cumberland Valley Retina Consultants

Hagerstown, Maryland, United States

Mid Atlantic Retina Specialists - Hagerstown

Hagerstown, Maryland, United States

Vitreo Retinal Associates, PC

Worcester, Massachusetts, United States

The Retina Institute

St Louis, Missouri, United States

Retina Center of New Jersey

Bloomfield, New Jersey, United States

Vision Research Center at Eye Associates of New Mexico

Albuquerque, New Mexico, United States

Retina Vitreous Surgeons of CNY, PC

Liverpool, New York, United States

Graystone Eye - Hickory Office

Hickory, North Carolina, United States

North Carolina Retina Associates

Wake Forest, North Carolina, United States

Retina Vitreous Center, PLLC

Edmond, Oklahoma, United States

Verum Research, LLC

Eugene, Oregon, United States

Wills Eye Hospital

Philadelphia, Pennsylvania, United States

Carolinas Centers for Sight, P.C. - Florence Campus

Florence, South Carolina, United States

Charles Retina Institute

Germantown, Tennessee, United States

Austin Clinical Research LLC

Austin, Texas, United States

Retina and Vitreous of Texas

Bellaire, Texas, United States

Retina Consultants of Texas

Bellaire, Texas, United States

San Antonio Eye Center

San Antonio, Texas, United States

Retina Associates of South Texas

San Antonio, Texas, United States

Retina Consultants of Texas

The Woodlands, Texas, United States

Tyler Retina Consultants

Tyler, Texas, United States

Strategic Clinical Research Group, LLC

Willow Park, Texas, United States

The Retina Group of Washington

Fairfax, Virginia, United States

Eye Clinic of Wisconsin

Wausau, Wisconsin, United States

Retina Prime at Jardim Europa Medical Center

Aracaju, Brazil

Centro Brasileiro de Pesquisa Clinica - Blumenau

Blumenau, Brazil

IPEPO - Instituto Paulista de Estudos e Pesquisas em Oftalmologia

São Paulo, Brazil

Retina Clinic-Jardim America

São Paulo, Brazil

UNIFESP - Hospital Sao Paulo

São Paulo, Brazil

VISUS, spol s.r.o.

Náchod, Czechia

Axon Clinical, s.r.o.

Prague, Czechia

Fakultni nemocnice Kralovske Vinohrady

Prague, Czechia

Vseobecna fakultni nemocnice v Praze

Prague, Czechia

Medical Private Care s.r.o.

Sokolov, Czechia

St Elisabeth Krankenhaus

Cologne, Germany

Bajcsy-Zsilinszky Korhaz es Rendelointezet

Budapest, Hungary

Budapest Retina Associates

Budapest, Hungary

EPC-Honvedkorhaz

Budapest, Hungary

Semmelweis Egyetem

Budapest, Hungary

Debreceni Egyetem KK Szemklinika

Debrecen, Hungary

Ganglion Medical Center

Pécs, Hungary

PTE KK Ophthalmology Clinic (Optimum Szemeszet)

Pécs, Hungary

SzTE KK Szemeszeti Klinika

Szeged, Hungary

View Full Details on ClinicalTrials.gov

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NCT07449923

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