RecruitingNCT07450820

OPTIMISE-CKD Study_Dapagliflozin Effectiveness in CKD

A Multinational, Observational, Retrospective, Secondary Data Study Analyzing Dapagliflozin Effectiveness in Routine Clinical Practice Among Patients With Chronic Kidney Disease. Local Adaptation for Spain. Part 2


Sponsor

AstraZeneca

Enrollment

14,308 participants

Start Date

Feb 18, 2026

Study Type

OBSERVATIONAL

Conditions

Summary

This is a retrospective, observational study, using secondary data captured in electronic health records (EHRs). The study is a part of the OPTIMISE-CKD program to assess the current CKD treatment landscape, Dapagliflozin utilisation and characterization of incident CKD patient and the burden of disease within an observation period of 39 months (August 2020-November 2024) in two cohorts (preand post-reimbursement of Dapagliflozin for CKD)


Eligibility

Min Age: 18 YearsMax Age: 130 Years

Plain Language Summary

Simplified for easier understanding

This real-world study is evaluating how well dapagliflozin — a medication originally developed for diabetes but now approved for chronic kidney disease — works in actual patients with chronic kidney disease (CKD) in routine clinical practice. The study uses health records to track kidney function and disease outcomes over time. **You may be eligible if:** - You are 18 years of age or older - You have chronic kidney disease, defined by having a consistently reduced kidney filtration rate (eGFR ≤60 mL/min on at least two readings at least 90 days apart) and/or elevated protein in your urine - You have been continuously enrolled in the healthcare database for at least 12 months before and after the start of dapagliflozin treatment **You may NOT be eligible if:** - You have Type 1 diabetes - You have been diagnosed with gestational diabetes Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Locations(1)

Research Site

Madrid, Spain

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NCT07450820


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