RecruitingNCT07450846

Incidence and Evolution of Heart-lung Interaction in Acute Respiratory Distress Syndrome

Incidence and Evolution of Heart-lung Interaction in Acute Respiratory Distress Syndrome: the IVOLIA Study


Sponsor

Bicetre Hospital

Enrollment

500 participants

Start Date

Dec 22, 2022

Study Type

OBSERVATIONAL

Conditions

Summary

Acute respiratory distress syndrome (ARDS) is an inflammatory injury of the lungs caused by various serious illnesses, such as a bacterial or viral lung infection. It is treated by artificial ventilation with the application of positive pressure. Pulmonary injury, coupled with artificial ventilation, can lead to right heart failure which hinders the ejection of blood to the pulmonary circulation. Modern mechanical ventilation modalities have reduced the frequency ("incidence") of this right heart failure in acute respiratory distress syndrome. A large-scale study has shown this a few years ago. However, the evolution of right heart failure during artificial ventilation, and the consequences it has on the patient's cardiovascular status are poorly determined. This study is conducted to improve knowledge in this area. In adult patients hospitalized in intensive care presenting acute respiratory distress syndrome, the investigators will collect the data recorded on cardiac ultrasound, doses of cardiovascular drugs as well as variables reflecting hemodynamic status and cell oxygenation. Data will be collected during the course of ARDS and mechanical ventilation, as well as after weaning from artificial ventilation.


Eligibility

Min Age: 18 Years

Plain Language Summary

Simplified for easier understanding

This observational study is tracking how the heart and lungs interact in patients with acute respiratory distress syndrome (ARDS) — a life-threatening condition where the lungs fill with fluid, making breathing extremely difficult and causing strain on the right side of the heart. Researchers will use regular echocardiograms (heart ultrasounds) to monitor how this interaction evolves during ICU treatment. **You may be eligible if:** - You are 18 years of age or older - You are hospitalized in an intensive care unit (ICU) and on a mechanical ventilator - You have been diagnosed with ARDS (acute respiratory distress syndrome) based on the Berlin definition - You are able to have at least one heart ultrasound (echocardiogram) within the first 24 hours of treatment, between days 2–3, between days 5–7, and within 48 hours of being taken off the ventilator **You may NOT be eligible if:** - You are pregnant - Your heart cannot be adequately visualized by ultrasound (poor imaging quality), preventing accurate measurement of heart dimensions Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Locations(1)

Chu de Bicêtre, AP-HP

Le Kremlin-Bicêtre, France

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NCT07450846


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