RecruitingNot ApplicableNCT07452614

Predicting Vital Pulp Treatment Outcomes in Symptomatic Pulpits Using Metabolic Biomarker

Efficacy of Metabolic Biomarkers in Predicting Twelve-Month Outcomes of Vital Pulp Treatment in Symptomatic Teeth With Carious Pulp Exposure: A Controlled Clinical Trial

Sponsor

Abeer Ghalib Abdul-khaliq

Enrollment

60 participants

Start Date

Feb 20, 2026

Study Type

INTERVENTIONAL

Conditions

Reversible Pulpitis Pulp Disease, Dental Pulpitis Irreversible Pulpitis (Toothache)

Summary

This prospective controlled clinical trial investigates whether metabolic biomarkers measured in pulpal blood at the time of carious pulp exposure can predict the 12-month outcomes of vital pulp treatment in symptomatic permanent teeth. Eligible patients aged 16-50 years presenting with deep carious pulp exposure will undergo vital pulp therapy (partial pulpotomy or full pulpotomy). Pulpal blood samples will be collected at the time of exposure and analyzed using High-Performance Liquid Chromatography (HPLC). Treatment outcomes will be assessed clinically and radiographically at 12 months. The study aims to identify objective, measurable biomarkers that can improve pulpal diagnosis and guide clinical decision-making in vital pulp therapy.

Eligibility

Min Age: 16 YearsMax Age: 50 Years

Inclusion Criteria5

Age range of 16-50 years.
Pulp exposure during treatment of deep caries.
Absence of periodontitis or systemic disease.
Only one or two proximal surfaces lost with remaining walls \> 2 mm; and
Good compliance and signed informed consent forms.

Exclusion Criteria7

Patients who meet any of the following criteria will be excluded:
Teeth with unrestorable large defects or the need for RCT for aesthetic reasons;
Teeth with a negative response to cold testing
Current pregnancy or breastfeeding;
Poor compliance or inability to complete the trial.
The use of medications, including antibiotics, bisphosphonates, or statins, within 3 weeks before the study.
Inadequate blood sample collection after pulpal exposure.

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Interventions

PROCEDUREvital pulp treatment

Vital pulp treatment (VPT) is defined by the European Society of Endodontology as a group of biologically based procedures aimed at preserving the health and function of the dental pulp that has been exposed or is at risk of exposure. These procedures involve removal of infected or inflamed tissue where necessary, protection of the remaining vital pulp with a biocompatible material, and placement of a definitive restoration to achieve a hermetic seal and support healing.