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RecruitingNot ApplicableNCT07453576

Effect Of Different Sodium Hypochlorite Concentrations On Intracanal Substance P, CGRP And Opiorphin Levels And Postoperative Pain During Root Canal Retreatment

Effect Of Different Sodium Hypochlorite Concentrations (%1, %2.5, And %5) On Intracanal Substance P, CGRP, And Opiorphin Levels And Postoperative Pain During Root Canal Retreatment: A Randomized Clinical Trial

Sponsor

KEZBAN MELTEM ÇOLAK

Enrollment

60 participants

Start Date

Oct 1, 2025

Study Type

INTERVENTIONAL

Conditions

Persistent Apical Periodontitis

Summary

This randomized clinical study aims to evaluate the effect of different sodium hypochlorite concentrations (1%, 2.5%, and 5.25%) used during root canal retreatment on intracanal levels of Substance P, CGRP, and Opiorphin, as well as postoperative pain. Patients requiring non-surgical root canal retreatment will be randomly assigned to one of three irrigation concentration groups. Intracanal samples will be collected before and after irrigation to measure neuropeptide levels. Postoperative pain will be assessed using a visual analog scale (VAS) at predetermined time intervals. The results of this study may help clarify the relationship between irrigant concentration, inflammatory mediators, and postoperative pain following root canal retreatment.

Eligibility

Min Age: 18 YearsMax Age: 65 Years

Inclusion Criteria4

  • Patients aged between 18 and 65 years.
  • Systemically healthy individuals (ASA I or II)
  • Patients requiring non-surgical root canal retreatment of a previously treated permanent tooth
  • Patients who provide written informed consent.

Exclusion Criteria9

  • Patients with systemic diseases that may affect pain perception or inflammatory response.
  • Use of analgesics, anti-inflammatory drugs, or antibiotics within 7 days prior to treatment.
  • Pregnant or lactating women.
  • Teeth with root fractures, perforations, advanced periodontal disease, or non-restorable teeth.
  • Teeth with open apices or immature root development.
  • Presence of acute apical abscess with swelling or sinus tract.
  • Patients with known allergy to sodium hypochlorite.
  • Inability to achieve adequate isolation with rubber dam.
  • Patients unable to attend follow-up or complete pain assessment forms.

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Interventions

DRUGSodium Hypochlorite 1% Irrigation

Irrigation with 1% sodium hypochlorite solution during chemomechanical preparation in non-surgical root canal retreatment. The solution will be used according to standardized irrigation protocols, and intracanal samples will be collected before and after irrigation for neuropeptide analysis.

DRUGSodium Hypochlorite 2.5% Irrigation

Irrigation with 2.5% sodium hypochlorite solution during chemomechanical preparation in non-surgical root canal retreatment. Intracanal samples will be collected before and after irrigation to evaluate changes in Substance P, CGRP, and Opiorphin levels.

DRUGSodium Hypochlorite 5% Irrigation

Irrigation with 5% sodium hypochlorite solution during chemomechanical preparation in non-surgical root canal retreatment. Intracanal samples will be obtained before and after irrigation, and postoperative pain will be assessed using a visual analog scale (VAS).

Locations(1)

Atatürk University Faculty of Dentistry, Department of Endodontics

Erzurum, Erzurum, Turkey (Türkiye)

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NCT07453576