RecruitingNCT07461610

Stool Analysis After Sleeve Gastrectomy vs Gastric Bypass

Routine Stool Parameters Six Months After Sleeve Gastrectomy vs. Gastric Bypass: Correlation With Weight Loss and Metabolic Outcomes

Sponsor

Cairo University

Enrollment

50 participants

Start Date

Apr 5, 2026

Study Type

OBSERVATIONAL

Conditions

Morbid Obesity

Summary

The goal of this observational study is to learn whether routine stool tests can detect changes in gut function 6 months after two common types of weight loss surgery: sleeve gastrectomy and gastric bypass (including mini gastric bypass and Roux-en-Y gastric bypass). The main questions it aims to answer are: Do stool tests show more signs of undigested food or carbohydrate malabsorption after gastric bypass compared to sleeve gastrectomy? Do signs of gut inflammation in stool (like fecal calprotectin) decrease after surgery, and does this relate to improvements in blood sugar and weight loss? Can simple stool test results at 6 months predict how much weight a person loses or how well their diabetes improves? Researchers will compare stool test results between the two surgery groups (sleeve gastrectomy vs. gastric bypass) to see if the type of surgery leads to different changes in gut health. Participants will: Provide a stool sample before surgery and again 6 months after surgery Provide a blood sample at the same time points to measure weight, blood sugar, and cholesterol Undergo their planned weight loss surgery as part of their regular medical care

Eligibility

Min Age: 18 YearsMax Age: 60 Years

Inclusion Criteria4

Male and female patients aged 18 to 60 years
Body Mass Index (BMI) ≥ 40 kg/m², OR BMI ≥ 35 kg/m² with at least one obesity-related comorbidity (type 2 diabetes, hypertension, dyslipidemia, osteoarthritis, obstructive sleep apnea)
Patients scheduled for primary laparoscopic bariatric surgery (either SG or Gastric Bypass \[MGB or RYGB\]) at Kasr Al-Ainy University Hospitals
Provision of written informed consent

Exclusion Criteria10

Age < 18 years or > 60 years
Previous bariatric surgery or major gastrointestinal surgery (gastric, intestinal, or colorectal resection)
Chronic kidney disease (eGFR < 60 mL/min/1.73m²) or previous renal transplant
Chronic liver disease (cirrhosis, chronic hepatitis) or liver failure
Chronic inflammatory bowel disease (Crohn's disease, ulcerative colitis), celiac disease, or chronic pancreatitis
Active malignancy or history of chemotherapy/radiotherapy in the past 5 years
Pregnancy or breastfeeding
Chronic alcohol abuse or substance abuse
Use of antibiotics, probiotics, or prebiotics within 4 weeks prior to stool sample collection (to avoid confounding effects on gut flora)
Acute gastrointestinal infection at the time of sample collection

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Interventions

PROCEDURELaparoscopic Sleeve Gastrectomy

Laparoscopic sleeve gastrectomy performed using a standard technique with a 36-Fr bougie, transecting the stomach starting 4-6 cm from the pylorus, excising the entire greater curvature and fundus. The staple line is inspected for hemostasis and leakage.

PROCEDUREMini Gastric Bypass

Laparoscopic mini gastric bypass performed using a standard technique with a long gastric tube created from the angle of His to the antrum, and a loop gastrojejunostomy with a biliopancreatic limb of 200 cm.

PROCEDURERoux-en-Y Gastric Bypass

Laparoscopic Roux-en-Y gastric bypass performed using a standard antecolic, antegastric technique. A small 30-mL gastric pouch is created. The biliopancreatic limb is 70-150 cm, and the alimentary (Roux) limb is 100-150 cm. Jejunojejunostomy is performed to restore continuity.