NUTRIBRAIN: Lifestyle Interventions to Prevent cOgnitive Deficits in Subjects With Depressive Symptoms: From mEchanisms to Clinical pRactice (POWER)

This study (called NUTRIBRAIN POWER) is testing whether lifestyle changes — such as diet, physical activity, and mental health strategies — can protect brain function and prevent memory or thinking problems in people aged 50 to 80 who have depression. Researchers are studying the link between depression, nutrition, and brain health. **You may be eligible if...** - You are between 50 and 80 years old - You have been diagnosed with major depressive disorder - You have no cognitive impairment, or only mild cognitive difficulties **You may NOT be eligible if...** - You are outside the 50–80 age range - You do not have a diagnosis of major depressive disorder - You have moderate to severe cognitive impairment or dementia Talk to your doctor to see if this trial is right for you.