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RecruitingNot ApplicableNCT07462013

NUTRIBRAIN: Lifestyle Interventions to Prevent cOgnitive Deficits in Subjects With Depressive Symptoms: From mEchanisms to Clinical pRactice (POWER)

DOUBLE-BLIND RANDOMIZED CLINICAL TRIALS TO SUSTAIN COGNITIVE FUNCTIONING VIA MODULATION OF GUT MICROBIOME AND INFLAMMATION FOR INDIVIDUALS AT RISK OF COGNITIVE DECLINE

Sponsor

National Science and Technology Council, Taiwan

Enrollment

120 participants

Start Date

Oct 1, 2025

Study Type

INTERVENTIONAL

Conditions

Major Depressive Disorder (MDD)

Summary

POWER project is a randomized, controlled, non-profit study with the primary objective of testing the effectiveness of non-pharmacological interventions-such as physical activity, cognitive training, and dietary supplementation-in reducing depressive symptoms and preventing or delaying cognitive impairments that frequently co-occur in individuals with Major Depressive Disorder (MDD).

Eligibility

Min Age: 50 YearsMax Age: 80 Years

Inclusion Criteria3

  • Aged 50-80 years old
  • Major Depressive Disorder
  • Absence or mild cognitive impairment

Exclusion Criteria1

  • \-

Interventions

DIETARY_SUPPLEMENTSoybean oil (Standard treatment)

3g/day of Soybean Oil

DIETARY_SUPPLEMENTEicosapentaenoic acid (omega-3 fatty acid)

3 grams/day

Locations(1)

Mind Body Interface Research Center (MBI Lab & Care)

Taichung, Taichung, Taiwan

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NCT07462013

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