Evaluation of Bile Acid Concentrations and Their Signaling as Markers of Testicular Tumorigenesis and Germ Cell Tumor Chemosensitivity
Evaluation of Bile Acid Concentrations and Their Signaling as Markers of Testicular Tumorigenesis and Germ Cell Tumor Chemosensitivity (TG-BIL)
University Hospital, Clermont-Ferrand
20 participants
Jan 1, 2026
INTERVENTIONAL
Conditions
Summary
This is a study exploring measurable markers in the blood of patients with testicular tumors. The investigators will focus on the importance of measuring and analyzing these markers for their prognostic value and predictive response to treatment.
Eligibility
Inclusion Criteria3
- Adult patient, male, with a clinical and biological diagnosis of germ cell tumor of the testis in pre-orchidectomy, at the stage of the disease and any histological subtype of germ cell tumor
- Affiliation with a Social Security organization
- Able to give informed consent to participate in the research.
Exclusion Criteria9
- Patient with a hepatobiliary pathology
- Patient treated with Colestyramine
- Patient who has undergone cholecystectomy or extensive resection of the small intestine
- Patient deprived of liberty
- Patient under guardianship, curatorship, or legal protection
- Patient unable to understand the protocol (language barrier, cognitive difficulties)
- Patient with another active cancer
- Patient participating in a therapeutic clinical trial
- Refusal to participate
Interventions
Blood samples will allow the measurement of AFP, LDH and HCG as well as the measurement of testosterone, glucose, cholesterol, triglycerides and bile acids
On these tissues (tumoral and non-tumoral), the investigators will carry out analysis of the bile acid composition by mass spectrometry, molecular characterization by RNAseq, histological characterization and analysis in cell culture
Locations(1)
View Full Details on ClinicalTrials.gov
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NCT07463508