RecruitingNot ApplicableNCT07463508

Evaluation of Bile Acid Concentrations and Their Signaling as Markers of Testicular Tumorigenesis and Germ Cell Tumor Chemosensitivity

Evaluation of Bile Acid Concentrations and Their Signaling as Markers of Testicular Tumorigenesis and Germ Cell Tumor Chemosensitivity (TG-BIL)


Sponsor

University Hospital, Clermont-Ferrand

Enrollment

20 participants

Start Date

Jan 1, 2026

Study Type

INTERVENTIONAL

Conditions

Summary

This is a study exploring measurable markers in the blood of patients with testicular tumors. The investigators will focus on the importance of measuring and analyzing these markers for their prognostic value and predictive response to treatment.


Eligibility

Sex: MALEMin Age: 18 Years

Plain Language Summary

Simplified for easier understanding

This study is investigating whether bile acids — natural chemicals in the digestive system — may play a role in testicular cancer development and how well the cancer responds to chemotherapy. Researchers will analyze blood samples from men with testicular cancer to measure bile acid levels. **You may be eligible if...** - You are an adult male - You have been clinically diagnosed with a germ cell tumor of the testis (a type of testicular cancer) - You are in the period before your testicle removal surgery - You are affiliated with a Social Security organization (in France) **You may NOT be eligible if...** - You are a minor (under 18) - You have already had your testicle removed - You do not have a germ cell tumor diagnosis Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

BIOLOGICALblood sampling

Blood samples will allow the measurement of AFP, LDH and HCG as well as the measurement of testosterone, glucose, cholesterol, triglycerides and bile acids

PROCEDURETissue sampling

On these tissues (tumoral and non-tumoral), the investigators will carry out analysis of the bile acid composition by mass spectrometry, molecular characterization by RNAseq, histological characterization and analysis in cell culture


Locations(1)

CHU Clermont-Ferrand

Clermont-Ferrand, France

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NCT07463508


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