RecruitingNot ApplicableNCT07464080

Advanced Brain Imaging-TKA (fMRI-TKA)

Brain Network-based Precision Medicine to Predict Dissatisfaction Following Total Knee Arthroplasty

Sponsor

Ottawa Hospital Research Institute

Enrollment

50 participants

Start Date

Apr 1, 2026

Study Type

INTERVENTIONAL

Conditions

Patient Satisfaction Knee Pain Chronic Knee Osteoarthritis (Knee OA)Brain Network Connectivity Brain MRI

Summary

Knee replacement surgery is a common and effective treatment for pain and mobility loss, yet up to 1 in 5 patients remain dissatisfied after surgery due to ongoing pain or difficulty with daily activities. Currently, clinicians cannot reliably predict which patients will experience these challenges. This study uses MRI scan of the brain to investigate whether specific patterns of brain activity can predict patient satisfaction after total knee arthroplasty (TKA). By comparing brain networks before surgery and afterward, and linking these changes to patient-reported pain and function, we aim to identify brain-based markers that can help predict outcomes, to improve satisfaction after knee replacement surgery.

Eligibility

Min Age: 18 Years

Inclusion Criteria3

Male and female patients aged 18 years or older
Primary TKA
Diagnosis of osteoarthritis, inflammatory arthritis, or osteonecrosis

Exclusion Criteria6

Inability or refusal to sign informed consent form
Non-English or French speaking, and no licensed translator, family member or substitute decision maker available
History of major neurological disorders (e.g traumatic brain injury, epilepsy, multiple sclerosis
Cognitive impairment or dementia
Revision and/or Bilateral TKA
Chronic Opioid use

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Interventions

PROCEDUREfMRI Brain Scan

A research brain MRI scan will be performed on a 3T scanner. The MRI session will take approximately 50 minutes of scanning time. The MRI scan will be repeated again 2 months after surgery.