Prefrontal Glutamatergic Modulation by NAC and MBCT for Depression in Youth

This study is testing a two-pronged approach to treating mild depression in young people: a supplement called NAC (N-acetylcysteine, which may support brain chemistry) combined with a type of mindfulness-based therapy called MBCT (Mindfulness-Based Cognitive Therapy). Researchers will also use brain scans to see how these treatments affect the brain. **You may be eligible if...** - You are between 15 and 24 years old - You have mild depression (diagnosed as a mild major depressive episode, persistent depressive disorder, or similar) - You are not currently taking psychiatric medications (or have been off them long enough) - You have reached a certain stage of puberty (Tanner stage III or above) **You may NOT be eligible if...** - You have significant suicide risk - You are currently on psychiatric medications (except stable ADHD stimulants) - You have moderate to severe depression or other serious psychiatric conditions - You are outside the 15–24 age range Talk to your doctor to see if this trial is right for you.