L-serine and Strength Training in the Elderly
University of Vienna
126 participants
Mar 1, 2026
INTERVENTIONAL
Conditions
Summary
This study investigates whether taking the amino acid L-serine, either alone or in combination with targeted strength training, can have a positive effect on mental performance, brain function, and physical fitness in older people. Healthy, independent women and men aged 65 to 85 are eligible to participate. Participants will be randomly assigned to one of three groups: placebo, L-serine, or L-serine combined with strength training. Cognitive tests, physical performance tests, and blood and brain tests will be conducted over a period of 48 weeks. The aim is to gain a better understanding of how nutrition and exercise can contribute to healthy aging.
Eligibility
Inclusion Criteria3
- Men and women between the ages of 65 and 85
- Mini-Mental-State >23
- Independently mobile, without aids (walker, cane, etc.)
Exclusion Criteria6
- Chronic diseases that contraindicate medical training therapy
- Regular strength training (>1x/week) in the last 6 months before confinement
- Frailty Index ≥ 3
- Lack of written consent to test physical performance
- Regular use of Cortison-containing medications or Antibiotika
- Non-compliance with the study protocol: <70% of the planned L-serine administration, <70% of the strength training
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Interventions
Structured strength training 2x/week
L-serine supplementation 6g/day
Placebo 6g cornstarch/day, No strength training
Locations(1)
View Full Details on ClinicalTrials.gov
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NCT07466290