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RecruitingPhase 2NCT07470359

Comparison of Functional Outcomes Following Arthroscopic ACL Reconstruction With Peroneus Longus Autograft With and Without Intra-articular Platelet-Rich Plasma Injection.

Comparison of Functional Outcomes Following Arthroscopic ACL Reconstruction With Peroneus Longus Autograft With and Without Intra-articular Platelet-Rich Plasma Injection: A Randomized Controlled Trial

Sponsor

Lahore General Hospital

Enrollment

60 participants

Start Date

Feb 20, 2026

Study Type

INTERVENTIONAL

Summary

This prospective RCT investigates if a single 4 ml intra-articular PRP injection improves knee function after ACL reconstruction using peroneus longus autograft. In Pakistan's resource-limited context, 88 patients (18-50 years) with isolated ACL tears receive either PRP or saline during surgery, then randomized equally. KOOS4 scores compared at 3, 6, and 12 months via ANCOVA (adjusted baseline, α=0.05). Positive results could establish affordable enhancement for recovery and guide practice in similar settings.

Eligibility

Min Age: 18 YearsMax Age: 50 Years

Inclusion Criteria1

  • Active individuals participating in sports or regular physical activity. Willingness to provide informed consent and adhere to the study protocol, including follow-up visits and rehabilitation.

Exclusion Criteria3

  • Significant chondral damage (Outerbridge grade > 2 on pre-operative MRI or intra-operative assessment).
  • Pre-existing knee osteoarthritis (Kellgren-Lawrence grade > 2). Systemic inflammatory conditions (e.g., rheumatoid arthritis). Bleeding disorders or coagulopathies. Current use of anticoagulants. Corticosteroid injection into the knee within 6 weeks prior to surgery. Pregnancy or lactation. Inability to comply with the rehabilitation protocol. Infection or history of infection in the affected knee. History of previous contralateral ACL injury (to isolate primary injury outcomes).
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Interventions

BIOLOGICALPRP injection

Platelets rich plasma from patients own blood

Locations(1)

Lahore General Hospital

Lahore, Punjab Province, Pakistan

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NCT07470359