RecruitingNCT07470593

Study of Glucose Tolerance Abnormalities Using Continuous Glucose Monitoring for the Identification of Early Loss of Pancreatic Islet Graft Function.

Prospective Longitudinal Observational Study of Glucose Tolerance Abnormalities Using Continuous Glucose Monitoring for the Identification of Early Loss of Pancreatic Islet Graft Function.


Sponsor

University Hospital, Strasbourg, France

Enrollment

36 participants

Start Date

Dec 15, 2025

Study Type

OBSERVATIONAL

Conditions

Summary

Islet transplantation is associated with drastically improvement glucose control in people with type 1 diabetes. This treatment resulted in the disappearance of severe hypoglycemic events. However, its long-term effectiveness is limited by progressive loss of graft function. Currently, there is no standardized method to detect early dysfunction of the transplanted islets. This study aims to determine whether a parameter derived from continuous glucose monitoring (CGM), Time in Tight Range (70-140 mg/dL), is associated with pancreatic islet grafts function. The study hypothesis is that a decrease in Time in Tight Range reflects early loss of islet graft function.


Eligibility

Min Age: 18 Years

Plain Language Summary

Simplified for easier understanding

This study is using continuous glucose monitoring (CGM) — a small wearable sensor that tracks blood sugar around the clock — to detect early signs that a transplanted pancreatic islet (insulin-producing cells) is losing function in people who received a pancreatic islet transplant for insulin-dependent diabetes. **You may be eligible if...** - You are 18 years of age or older - You have insulin-dependent diabetes (Type 1 diabetes, or diabetes from chronic pancreatitis, cystic fibrosis, or a rare genetic form called MODY) - You have completed a full pancreatic islet transplant procedure - You have agreed to allow your data to be used for this research **You may NOT be eligible if...** - You refuse to wear a continuous glucose monitor - You had an islet autotransplant (where your own cells were transplanted, not a donor's) - You are unable to provide informed consent - You are under legal guardianship or judicial protection Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

OTHERContinuous glucose monitoring (CGM) with TITR measurement

Continuous glucose monitoring (CGM) with TITR measurement


Locations(1)

Hopitaux Universitaires de Strasbourg

Strasbourg, France

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NCT07470593


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