RecruitingPhase 2Phase 3NCT07472140

PARP (Poly (ADP-ribose) Polymerase) Inhibitor With or Without Angiogenesis Inhibitor in Homologous Recombination Deficient Primary Ovarian Cancer, Fallopian-Tube Cancer, or Primary Peritoneal Cancer

To Develop and Implement The Scope of Medical Care for Homologous Recombination Deficient Ovarian Cancer, Fallopian-Tube Cancer, or Primary Peritoneal Cancer of the III-IV Stages Using Maintenance Therapy With PARP Inhibitor Combined With Angiogenesis Inhibitor.


Sponsor

N.N. Alexandrov National Cancer Centre

Enrollment

120 participants

Start Date

Jul 1, 2025

Study Type

INTERVENTIONAL

Conditions

Summary

This is a randomized trial evaluating the results of using of PARP inhibitor combined with angiogenesis inhibitor. in patients with homologous recombination deficient primary ovarian cancer, fallopian-tube cancer, or primary peritoneal cancer of the III-IV stages.


Eligibility

Sex: FEMALEMin Age: 18 YearsMax Age: 75 Years

Plain Language Summary

Simplified for easier understanding

This trial is studying two targeted cancer drugs — a PARP inhibitor and a drug that blocks blood vessel growth (angiogenesis inhibitor) — in women with a newly diagnosed type of ovarian, fallopian tube, or peritoneal cancer that has a specific DNA repair flaw called homologous recombination deficiency (HRD). Researchers want to know if combining both drugs works better than the PARP inhibitor alone. **You may be eligible if...** - You are between 18 and 75 years old - You have been diagnosed with high-grade serous or endometrioid ovarian, fallopian tube, or peritoneal cancer - Your tumor has tested positive for a DNA repair problem called HRD - You are well enough to carry out light activity (good general health status) - You are able to undergo a diagnostic or surgical procedure **You may NOT be eligible if...** - You have another active cancer - You are pregnant or breastfeeding - Your cancer has already progressed during treatment Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

DRUGPARP inhibitor + Bevacizumab

Patients will receive 6 courses of chemotherapy according to the regimen of platinum drug + paclitaxel + bevacizumab (≥3 cycles) every 21 days. In case of a complete or partial response maintenance therapy is carried out until disease progression or intolerable toxicity or for 2 years to the regimen of PARP inhibitor + bevacizumab.

DRUGPARP inhibitor

Patients will receive 6 courses of chemotherapy according to the regimen of platinum drug + paclitaxel every 21 days. In case of a complete or partial response maintenance therapy of PARP inhibitor is carried out until disease progression or intolerable toxicity or for 2 years.


Locations(1)

N.N. Alexandrov National Caner Centre

Minsk, Lesnoy, Belarus

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NCT07472140


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