Comparative Study for Facial Scar Remodeling Using Fractional Carbon Dioxide Laser Combined With PDRN Versus Fractional CO₂ Laser
Comparative Study for Facial Scar Remodeling Using Fractional Carbon Dioxide Laser Combined With Polydeoxyribonucleotide (PDRN) Versus Fractional CO₂ Laser: A Randomized Controlled Clinical Study
Misr University for Science and Technology
36 participants
Mar 1, 2026
INTERVENTIONAL
Conditions
Summary
Facial scars are frequently deemed unpleasant and can profoundly impact a patient's psychological health. This study compares the effectiveness, safety, and capacity to speed up scar healing in the maxillofacial region between fractional carbon dioxide (CO₂) laser therapy alone and polydeoxyribonucleotide (PDRN) combined with CO₂ laser therapy.
Eligibility
Inclusion Criteria3
- Age Limitations: Participants must be between 18 and 50 years of age.
- Recently cut wounds or surgical scars from about (1-6 months).
- Consent to Participate: Willingness to provide informed consent and engage in all aspects of the study.
Exclusion Criteria8
- Pregnancy or breastfeeding at the time of study.
- Known allergy to PDRN.
- Medication use that could affect wound healing or inflammation, such as:
- Isotretinoin.
- Anticancer drugs.
- High-dose corticosteroids.
- Anticoagulants.
- Uncontrolled medical diseases (e.g., unstable diabetes, cardiac conditions).
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Interventions
intralesional PDRN injections
Fractional carbon dioxide (CO₂) laser therapy for facial scars
Locations(1)
View Full Details on ClinicalTrials.gov
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NCT07472192