RecruitingNot ApplicableNCT07473648

Multimodal Clinical Study of Electroconvulsive Therapy and Magnetic Seizure Therapy

Sponsor

The Second Hospital of Anhui Medical University

Enrollment

200 participants

Start Date

Sep 1, 2025

Study Type

INTERVENTIONAL

Conditions

Major Depressive Disorder Electroconvulsive Therapy Magnetic Seizure Therapy

Summary

To compare the efficacy and tolerability of Electroconvulsive Therapy (ECT) and Magnetic Seizure Therapy (MST) in patients with major depressive disorder (MDD).

Eligibility

Min Age: 12 YearsMax Age: 80 Years

Inclusion Criteria2

Aged 12-80 years; Diagnosis confirmed by two psychiatrists per DSM-5; Stable medication regimen pre-enrollment; Indicated for neuromodulation OR with visual field defects.
Aged 12-80 years; No history of neuropsychiatric disorders; No significant systemic diseases; Normal or corrected vision.

Exclusion Criteria2

Major systemic diseases; Prior neuromodulation within 3 months; Pregnancy or potential pregnancy; Metal implants or claustrophobia.
Metal implants or claustrophobia; Ocular diseases or surgery history.

Interventions

DEVICEElectroconvulsive Therapy

Electroconvulsive therapy will be administered two to four times a week according to a standardized protocol. Stimulation parameters (including intensity, target location, session number, and duration) will be individualized for each participant based on prior research to ensure targeted and safe delivery within established safety limits. Treatment will continue until the participant meets the protocol-defined response criteria or completes a maximum of 10 sessions.

DEVICEMagnetic Seizure Therapy

Magnetic seizure therapy will be administered two to four times a week according to a standardized protocol. Stimulation parameters (including intensity, target location, session number, and duration) will be individualized for each participant based on prior research to ensure targeted and safe delivery within established safety limits. Treatment will continue until the participant meets the protocol-defined response criteria or completes a maximum of 10 sessions.

OTHERCognitive and Behavioral Assessment

Participants will undergo a series of standardized cognitive tests (e.g., MCCB) and behavioral assessments (e.g., clinical rating scales) at specified time points. This does not constitute a therapeutic intervention but is for the purpose of data collection to establish normative baseline performance.