Radiofrequency Ablation For Recurrent Parathyroid Carcinoma
M.D. Anderson Cancer Center
20 participants
Apr 9, 2026
INTERVENTIONAL
Conditions
Summary
The study will be an effectiveness study. The study will include enrollment of a total of 20 patients with at least one PC lesion for ultrasound guided RFA to PC recurrence in the neck to assess the effectiveness in reducing patient's hypercalcemia. Patients will have surgically proven PC from prior parathyroidectomy and suspicious PC visible on ultrasound and request for treatment for uncontrolled hypercalcemia (Figure 1).
Eligibility
Inclusion Criteria13
- Patient is older than 18 years, is not a surgical candidate or refuses to have surgery.
- Patient is medically fit to undergo local anesthesia with or without conscious sedation.
- Patient is able to understand and give consent to participation in the study.
- Confirmed parathyroid carcinoma by prior surgery and histopathology.
- Presence of local recurrence or implant in the neck visible on ultrasound.
- Distant oligometastasis visible on ultrasound.
- Solid nodule without macrocalcification or internal cystic degeneration
- Patient who is off of Cinacalcet
- Entirety of the selected nodule is visible on ultrasound without significant extension posterior to trachea or mediastinal component (ie Type A, E, or high F).
- Selected nodule is amenable to medial or lateral approach.
- Normal complete blood count, blood coagulation.
- Patient agrees to participate in the clinical study and to complete all required visits and evaluations.
- Negative serum or urine pregnancy test for females of childbearing potential at baseline pre-procedure evaluation.
Exclusion Criteria10
- Candidates will be ineligible for enrollment in the study if any of the following conditions apply:
- Patients with cardiac arrhythmia and/or implanted cardiac device
- Surgically naïve parathyroid lesions, parathyroid adenoma or atypical parathyroid tumor.
- Pregnancy
- Allergies to medications for anesthesia.
- Cystic nodules (< 70% solid components)
- Calcified nodules
- Targeted nodule within 0.5 cm from the major vessels, vagus nerve, brachial plexus, and recurrent laryngeal nerve.
- Patients with contralateral vocal cord paralysis.
- Uncorrectable coagulopathy with PTT>1.5 X ULN or INR >1.5 or platelet count <100,000 per mm3
Interested in this trial?
Get notified about updates and connect with the research team.
Interventions
Participants will be positioned supine with full neck extension. Preprocedural intraoperative PTH will be drawn. Radiofrequency ablation (RFA) will be performed on one or up to 5 nodules on ipsilateral side per participant.
Locations(1)
View Full Details on ClinicalTrials.gov
For the most up-to-date information, visit the official listing.
NCT07475780