Brief Title: Aerobic Training on Cerebrovascular Function, Cognition and Gait in Parkinson's Disease
Effects of Aerobic Training on Cerebrovascular Function, Cognitive Performance and Gait Parameters in Patients With Parkinson's Disease: A Randomized Controlled Trial
Raphael Mendes Ritti Dias
40 participants
Feb 28, 2026
INTERVENTIONAL
Conditions
Summary
This randomized controlled trial will investigate the effects of a 12-week supervised aerobic training program on cerebrovascular function, peripheral vascular health, cardiovascular autonomic modulation, cognition, non-motor symptoms, sleep, mood, gait biomechanics, quality of life, and body composition in patients with Parkinson's disease (Hoehn \& Yahr stages 1-3). Participants will be randomly allocated to aerobic training or usual care.
Eligibility
Inclusion Criteria6
- Clinical diagnosis of Parkinson's disease
- Hoehn \& Yahr stages 1-3
- Stable antiparkinsonian medication for at least 4 weeks
- Montreal Cognitive Assessment (MoCA) score ≥ 18
- Ability to walk independently (with or without assistive device)
- Medical clearance for participation in moderate-intensity exercise
Exclusion Criteria2
- Change in medication
- Contraindication to exercise
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Interventions
Aerobic Exercise Training
Usual Care
Locations(1)
View Full Details on ClinicalTrials.gov
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NCT07478146