Berberine Supplementation, Sprint Interval Training, and Immune Function Study
Effects of 2-Weeks of Berberine and Sprint Interval Training on Wellbeing, Anaerobic Power, and Monocyte Number and Function
University of Northern Colorado
40 participants
Jan 1, 2026
INTERVENTIONAL
Conditions
Summary
The purpose of this clinical trial is to investigate the effects of a 2-week intervention involving berberine supplementation or sprint training in isolation as well as berberine combined with sprint training on well-being, anaerobic power, and monocyte number and function in individuals experiencing mild mental health challenges. The main questions it aims to answer are: * Does short-term berberine use or sprint training improve measures of mental health, psychological wellbeing, fatigue, and sleep quality? * Does short-term berberine use or sprint training improve measures of anaerobic power generation? * Does short-term berberine use or sprint training improve circulating biomarkers of inflammation? * Does short-term berberine use or sprint training improve monocyte number, function, and cytokine production?
Eligibility
Inclusion Criteria3
- Males and Females
- Aged 18-45
- DASS-21 subscale scores indicating "Mild" or greater category for Depression ≥ 10, Anxiety ≥ 7, and Stress ≥ 11
Exclusion Criteria8
- Regular berberine intake in the last 2 months
- Performs SIT regularly in the last month
- Pregnant or planning to become pregnant
- Chronic use of anti-inflammatory medication or medications that affect liver metabolism
- Prior history of chronic conditions such as Cardiovascular Disease, Diabetes, and Cancer
- Severe and untreated anxiety or depression
- Severe Peanut Allergies
- Any contraindications to performing high intensity exercise
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Interventions
Consumption of a commercially-available Berberine supplement at a dosage of 500mg, Three times per day with meals, for a total dosage of 1500mg/day.
Consumption of placebo capsules composed of rice flour at a dosing of 3 capsules per day with meals.
Multiple sets of maximal effort 30 second sprints, inter spaced with 4 minutes of rest/active recovery, on the cycle ergometer over the course of 6 sessions during the 2-Week intervention. Resistance for each set is calculated at 7.5% of the body mass of the participant. Sets for each session are as follows: (1) 4 Sets, (2) 5 Sets, (3) 6 Sets, (4) 6 Sets, (5) 7 Sets, (6) 4 Sets.
Locations(1)
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NCT07480018