RecruitingNot ApplicableNCT07482501

Repetitive Transcranial Magnetic Stimulation in Cardiac Autonomic Dysfunction

The Effect of Repetitive Transcranial Magnetic Stimulation on Cardiac Autonomic Dysfunction in Patients With Stroke

Sponsor

Afyonkarahisar Health Sciences University

Enrollment

44 participants

Start Date

Mar 26, 2026

Study Type

INTERVENTIONAL

Conditions

Hemiparesis Autonomic Dysfunction Stroke

Summary

The aim of this study is to investigate the effects of repetitive transcranial magnetic stimulation (rTMS) added to conventional neurological rehabilitation on heart rate variability (HRV), quality of life, upper extremity muscle strength and autonomic symptoms in patients with stroke.

Eligibility

Min Age: 35 YearsMax Age: 80 Years

Inclusion Criteria4

Participants aged 35-80 years admitted to the Afyonkarahisar Health Sciences University Hospital Physical Medicine and Rehabilitation Unit for neurological rehabilitation after stroke
Participants with a history of stroke of at least 3 months
Neurologically and medically stable participants willing to participate regularly in the study
Participants capable of following commands

Exclusion Criteria12

Serious cardiac disease, uncontrolled hypertension
Epilepsy or history of antiepileptic drug use
Intracranial metallic implants
Inner ear implants
Malignancy
Active infection
Skin infection or open wound in the intervention area
Brain lesions or medications that may alter the seizure threshold
Increased intracranial pressure
Uncontrolled migraine
Fracture or surgery on the hemiplegic side within the last 6 months
Pregnancy

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Interventions

DEVICErTMS M1 Motor Cortex Protocol

Repetitive transcranial magnetic stimulation (rTMS) will be applied using the MagVenture MagPro R30 device with a Figure Eight Coil according to the study protocol. rTMS will be delivered to the contralateral primary motor cortex (M1) upper extremity motor area at a low frequency of 1 Hz, 5 sessions per week for 4 weeks, totaling 20 sessions.

DEVICESham rTMS Protocol

Sham (placebo) repetitive transcranial magnetic stimulation (rTMS) will be applied to mimic the procedure without delivering active stimulation. It was planned to apply it daily for 20 sessions.