RecruitingPhase 1Phase 2NCT07482709

Comparison Between Tranversus Abdominis Plane (TAP) Block With Only Bupivacaine and TAP Block With Bupivacaine Plus Ketamine in Reducing Postoperative Pain After Total Abdominal Hystrectomy

Transversus Abdominis Plane Block : A Comparative Study Between Bupivacaine vs Bupivacaine With Ketamine in Total Abdominal Hystrectomy


Sponsor

Liaquat National Hospital & Medical College

Enrollment

30 participants

Start Date

Nov 1, 2025

Study Type

INTERVENTIONAL

Conditions

Summary

The goal of this study is to know how effectively TAP block can reduce postoperative pain in total abdominal hystrectomy patients when given ketamine in addition to bupivacaine in TAP block and to compare it with the conventional TAP block with bupivacaine only. The main question it aims to answer is: Does intervention with ketamine in TAP block lowers the postoperative pain measured via visual analog scale and decreases the need for rescue analgesia? Patients will be assessed for pain in PACU( post anesthesia care unit), 6 hours, 12 hours and 24 hours postoperatively. Time of rescue analgesia will also be noted if given.


Eligibility

Sex: FEMALEMin Age: 25 YearsMax Age: 65 Years

Inclusion Criteria3

  • Aged between 25 to 60 years.
  • ASA grade I \& II.
  • Undergoing total abdominal hysterectomy.

Exclusion Criteria7

  • BMI >35kg/m2.
  • Patient refusal for participation.
  • Patients with coagulation disorders.
  • Patents with history of allergy and hypersensitivity to local anesthetic.
  • Patient having infection at the injection site.
  • Alcohol or drug abuse.
  • Cognitive or mental disorder.

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Interventions

DRUGbupivicaine 0.25%

20ml of 0.25% bupivacaine inTAP block

DRUGbupivicaine 0.25% + ketamine

20ml of 0.25% of bupivacaine with 50mg ketamine in TAP block


Locations(1)

gynae operation theatre at Liaquat National Hospital

Karachi, Sindh, Pakistan

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NCT07482709