Cerebellum-based Imaging Neural Markers for Antipsychotic Response

This study is using brain imaging to look for biological markers in the cerebellum (the part of the brain that coordinates movement and has recently been linked to psychiatric conditions) that might predict how well someone responds to antipsychotic medications. Understanding these markers could help doctors choose the right treatment sooner for people experiencing their first episode of psychosis. **You may be eligible if...** - You are aged 16–40 and have been diagnosed with a first-episode psychotic disorder (such as schizophrenia, schizoaffective disorder, bipolar disorder with psychosis, or major depression with psychosis) - You are currently experiencing moderate to severe psychotic symptoms (such as hallucinations or disorganized thinking) - You have taken antipsychotic medications for no more than 8 weeks total in your lifetime - You are able to provide informed consent **You may NOT be eligible if...** - You have a serious neurological or hormonal disorder, or a history of brain injury - You have a medical condition requiring a medication that affects mental function - You are at significant risk of harming yourself or others - You have a contraindication to antipsychotic medications - You cannot undergo an MRI scan (e.g., due to a pacemaker) - You are pregnant Talk to your doctor to see if this trial is right for you.