Deep Versus Moderate Neuromuscular Blocking
The Effect of Deep Versus Moderate Neuromuscular Blocking on Patients Undergoing Open Hysterectomy
Menoufia University
88 participants
Feb 1, 2026
INTERVENTIONAL
Conditions
Summary
This study aimed for Determination of the impacts of deep neuromuscular blockade (DNMB) on surgical outcomes, consumption of perioperative opioid analgesia, and serum levels of inflammatory cytokines in comparison to moderate NMB (MNMB).
Eligibility
Inclusion Criteria3
- Women who will be admitted to undergo elective hysterectomy
- ,-ASA grade I or II,
- Body mass index (BMI) of \<35 kg/m2
Exclusion Criteria5
- hemoglobin concentration of ≤7 gm%,
- the presence of neuromuscular disorders
- uncontrolled medical diseases
- autoimmune diseases, maintenance on immunosuppressant therapy for any indication
- refusal to sign the written consent
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Interventions
A TOF-Watch® SX-acceleromyograph will be applied to the adductor pollicis muscle and calibrated to monitor response and degree of NMB. Anesthesia will be induced with IV propofol (1.5-2.5 mg/kg) and rocuronium bromide 0.6 mg/Kg, and the trachea will be intubated at train-of-four (TOF) 0. Anesthesia will be maintained with 50% air in oxygen and an end-tidal concentration of 2-3% sevoflurane. In the DNMB group, rocuronium infusion was used to provide 0.48-0.72 mg/kg/h to maintain PTC 0-1.
For patients in the MNMB group, rocuronium will be given as 0.2 mg/kg to maintain a post-tetanic count (PTC) of \>1, and TOF in the range of 0-2.
Locations(1)
View Full Details on ClinicalTrials.gov
For the most up-to-date information, visit the official listing.
NCT07485517