RecruitingNot ApplicableNCT07485738

The Relationship Between Blood Flow Readings During Surgery and How Well the Graft Stays Open and How Patients Recover Afterward in Coronary Artery Bypass Graft Surgery

Surgical Measurement for Accurate Revascularization Using Transit-time FLOW (SMARTFLOW):Patency

Sponsor

Weill Medical College of Cornell University

Enrollment

1,242 participants

Start Date

Mar 30, 2026

Study Type

INTERVENTIONAL

Conditions

Heart Disease CABG Blood Flow CABG Graft Integrity Transit-time Flow Measurement

Summary

The purpose of this study is to learn more about a tool called Transit-Time Flow Measurement (TTFM). TTFM uses sound waves during surgery to check how well blood is flowing through blood vessels. This helps doctors see if the blood flow is good during coronary artery bypass grafting (CABG), which is a type of heart surgery

Eligibility

Min Age: 18 Years

Inclusion Criteria3

Age >18 years
First-time, non-emergent isolated multivessel CABG through median sternotomy
Willing and able to provide written informed consent and comply with all study procedures, including QOL questionnaires

Exclusion Criteria7

Reoperation
Emergency procedures
Combined CABG + other cardiac or non-cardiac surgery
Isolated single vessel CABG
Minimally invasive CABG
Inability to undergo coronary computed tomographic angiography (CCTA)
Unable to provide written informed consent or comply with all the study procedures.

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Interventions

DEVICETransit-Time Flow Measurement (TTFM)

TTFM is based on ultrasound technology and allows the assessment of intraoperative graft function based on quantification, directionality and resistance to blood flow through the graft.