RecruitingPhase 4NCT07485803

Methadone in the Management of Post-Operative Pain in Total Knee Replacement

A Prospective, Randomized Trial Utilizing Methadone in the Management of Post-Operative Pain in Total Knee Replacement

Sponsor

AdventHealth

Enrollment

192 participants

Start Date

Jun 1, 2026

Study Type

INTERVENTIONAL

Conditions

Total Knee Arthroplasty

Summary

The goal of this study is to determine whether one dose of IV methadone given right before surgery will help patients' pain management after a total knee replacement and reduce the amount of pain medications taken in the weeks after surgery.

Eligibility

Min Age: 21 YearsMax Age: 75 Years

Plain Language Summary

Simplified for easier understanding

This clinical trial is studying a drug called Methadone for people with total knee arthroplasty. The study is currently recruiting participants at 1 location. People eligible for this study include aged 21 Years to 75 Years.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

DRUGMethadone

Subjects randomized to receive methadone will be given one dose of methadone 0.15mg/kg intravenously dosed based on ideal body weight administered by the anesthesia team prior to surgical incision