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RecruitingPhase 3NCT07486544

Soaked Pharyngeal Packing Agents in Septoplasty

Comparative Evaluation of Soaked Pharyngeal Packing Agents in Septoplasty Procedure: Impact on Postoperative Outcomes

Sponsor

Assiut University

Enrollment

90 participants

Start Date

Mar 20, 2026

Study Type

INTERVENTIONAL

Summary

Postoperative sore throat (POST) is a frequent and distressing complication after general anesthesia with endotracheal intubation, particularly in nasal surgery for example, functional endoscopic sinus surgery, septoplasty, or septo-rhinoplasty, where pharyngeal packing is routine. While pharyngeal packs may reduce blood ingestion, they may exacerbate POST, warranting effective pharmacologic prophylaxis. This study assesses the efficacy of dexamethasone-soaked pharyngeal packs in reducing incidence of POST in patients undergoing elective septoplasty surgeries.

Eligibility

Min Age: 18 YearsMax Age: 65 Years

Inclusion Criteria4

  • Adults aged 18 to 65 years,
  • Both male and female,
  • Classified as American Society of Anesthesiologists (ASA) physical status I to III, and
  • Scheduled for elective septoplasty.

Exclusion Criteria11

  • Preoperative sore throat,
  • Recent upper respiratory infections,
  • Anticipated difficult airway,
  • Existing digestive, respiratory, or cervical conditions,
  • Regular smoking,
  • Steroid use within 48 hours prior to surgery, and
  • Pregnancy.
  • Patients on chronic corticosteroid therapy, antitussives, or antihypertensive medications
  • With known effects on airway reactivity or bleeding risk,
  • Those with uncontrolled hypertension, or
  • With known allergies to any of the study medications or their components

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Interventions

OTHERSaline (NaCl 0,9 %) (placebo)

The anesthetist, unaware of group allocation, will place the saline soaked pharyngeal pack under direct visualization following intubation. The pharyngeal pack will be situated in the oropharynx, positioned posterior to the soft palate and in contact with the posterior pharyngeal wall. Placement will be executed with forceps under direct observation, adhering to a standardized protocol to guarantee uniformity across all patients.

DRUGdexamethasone 8mg

The anesthetist, unaware of group allocation, will place the dexamethasone soaked pharyngeal pack under direct visualization following intubation. The pharyngeal pack will be situated in the oropharynx, positioned posterior to the soft palate and in contact with the posterior pharyngeal wall. Placement will be executed with forceps under direct observation, adhering to a standardized protocol to guarantee uniformity across all patients.

Locations(1)

Assiut University

Asyut, Egypt

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NCT07486544