RecruitingNCT07491094

Repeated Examinations for Typing Pulmonary Embolism

Repeated Examinations for Typing Pulmonary Embolism (RE-TyPE)

Sponsor

Sahlgrenska University Hospital

Enrollment

400 participants

Start Date

Apr 1, 2026

Study Type

OBSERVATIONAL

Conditions

Pulmonary Embolism (PE)Pulmonary Embolism (Diagnosis)Pulmonary Embolism Acute Pulmonary Embolism With Acute Cor Pulmonale Pulmonary Embolism With Right Ventricle Enlargement

Summary

PURPOSE The two related purposes of the RE-TyPE study are: 1. To improve understanding of the early clinical course of intermediate-high risk pulmonary embolism and its association with outcome and 2. To establish a platform for longitudinal follow-up for all pulmonary embolism at Sahlgrenska University Hospital HYPOTHESES 1. The dynamic pattern of change, evaluated thorough repeated measures of biomarkers, electrocardiography and echocardiography during the first 48 hours after pulmonary embolism, better predicts outcome than static measurements currently used to predict outcome 2. Establishment of a platform for longitudinal follow-up will improve quality of care and outcome for patients with pulmonary embolism at Sahlgrenska University Hospital

Eligibility

Min Age: 18 Years

Inclusion Criteria2

Adult patients (≥ 18 years old) who is diagnosed with, or followed as out-patients for, PE at Sahlgrenska University Hospital
Written informed consent

Exclusion Criteria4

Low risk, intermediate-low risk or high risk PE*
>48 hours since arrival to hospital
Expected inability to comply with the protocol (e.g. dementia)
*If biomarkers (and/or echocardiography) are not available in hemodynamically stable patients, RV/LV-ratio >1 will be considered as preliminary intermediate-high risk. If biomarkers later fall out negative, the patient will be considered as intermediate-low risk and will be moved to Cohort B

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