RecruitingNot ApplicableNCT07491718

Manganese-enhanced Magnetic Resonance Imaging in Takotsubo Cardiomyopathy


Sponsor

University of Edinburgh

Enrollment

100 participants

Start Date

Aug 8, 2025

Study Type

INTERVENTIONAL

Conditions

Summary

The goal of this research study is to further understand the physiological mechanisms involved in a heart condition called takotsubo cardiomyopathy, also known as broken heart syndrome. Furthermore, the investigators will be assessing the effects different cardiac medications have on these physiological mechanisms. This will be achieved by performing cardiac MRI scans using a special dye called manganese. Manganese uptake in the heart is altered in patients with takotsubo cardiomyopathy. The investigators will study the effects that different cardiac medications have on manganese uptake.


Eligibility

Min Age: 18 Years

Plain Language Summary

Simplified for easier understanding

This clinical trial is studying a drug called Bisoprolol, a drug called Dapagliflozin (10mg Tab), and others for people with takotsubo cardiomyopathy. The study is currently recruiting participants at 1 location.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

DRUGBisoprolol

Participants will be randomised to receive Bisoprolol medication.

DRUGValsartan

Participants will be randomised to receive Valsartan medication.

DRUGsacubitril/ valsartan

Participants will be randomised to receive Sacubitril/Valsartan medication first.

DRUGDapagliflozin (10mg Tab)

Participants will be randomised to receive Dapaglifozin medication first.

DRUGNo medications

Participants will be randomised to receive no study medication.


Locations(1)

University of Edinburgh

Edinburgh, United Kingdom

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NCT07491718


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