RecruitingPhase 2NCT07501702

A Phase 2 Study to Evaluate Povetacicept in Adults With Generalized Myasthenia Gravis

A Phase 2, Multicenter, Randomized, Double-Blind, Placebo-Controlled Study With a Long-term Extension of Povetacicept in Adults With Generalized Myasthenia Gravis

Sponsor

Vertex Pharmaceuticals Incorporated

Enrollment

30 participants

Start Date

May 13, 2026

Study Type

INTERVENTIONAL

Conditions

Myasthenia Gravis, Generalized

Summary

The purpose of this study is to evaluate the pharmacodynamic (PD) effect, safety, and tolerability of Povetacicept in participants with generalized myasthenia gravis (gMG).

Eligibility

Min Age: 18 Years

Plain Language Summary

Simplified for easier understanding

This clinical trial is studying a drug called Placebo and a drug called Povetacicept for people with myasthenia gravis, generalized. The study is currently recruiting participants at 17 locations. People eligible for this study include aged 18 Years to 80 Years.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

DRUGPovetacicept

Solution for Subcutaneous Injection.

DRUGPlacebo

Solution for Subcutaneous Injection.

Locations(28)

Tri Valley Neurology Medical Associates Inc.

Mission Hills, California, United States

Neurology Offices

Boca Raton, Florida, United States

SFM Clinical Reseach, LLC

Boca Raton, Florida, United States

Homestead Associates in Research

Homestead, Florida, United States

UF Health Jacksonville Respiratory Therapy (PFT and DLCO)

Jacksonville, Florida, United States

Y & L Advance Health Care, Inc D/B/A Elite Clinical Research - Neurology

Miami, Florida, United States

Quantix Research

Miami, Florida, United States

Hawaii Pacific Neuroscience

Honolulu, Hawaii, United States

HSHS Medical Group - St. Elizabeth's Hospital

O'Fallon, Illinois, United States

Las Vegas Neurology Center

Las Vegas, Nevada, United States

Clinical Trials of South Carolina - Neurology

Charleston, South Carolina, United States

Ut Erlanger Neurology

Chattanooga, Tennessee, United States

Nerve and Muscle Center of Texas - Neurology

Houston, Texas, United States

Texas Institute for Neurological Disorders

Sherman, Texas, United States

Neurology Care Clinic

Waxahachie, Texas, United States

Eastern Health - Box Hill Hospital

Box Hill, Australia

MICS Centrum Medyczne Bydgoszcz

Bydgoszcz, Poland

Neurologia Slaska Centrum Medyczne

Katowice, Poland

Clinical Research Center Sp. z o.o., Medic-R Sp. K.

Poznan, Poland

NZOZ NEURO-KARD Ilkowski i Partnerzy Sp. Partnerska Lekarzy

Poznan, Poland

Twoja Przychodnia Poznanskie Centrum Medyczne Sp. z o. o.

Poznan, Poland

Centrum Medyczne Neuroprotect

Warsaw, Poland

ETG Neuroscience

Warsaw, Poland

Istanbul University Medical Faculty

Fatih, Turkey (Türkiye)

Kocaeli University Medical Faculty

Kocaeli, Turkey (Türkiye)

University Hospitals Birmingham NHS Foundation Trust - Queen Elizabeth Hospital

Birmingham, United Kingdom

St. George's University Hospital

London, United Kingdom

Northern Care Alliance NHS Foundation Trust - Salford Royal Hospital

Salford, United Kingdom

View Full Details on ClinicalTrials.gov

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NCT07501702

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