RecruitingNot ApplicableNCT07507344

Beverage Hydration Index of Different Solutions

Comparison of the Beverage Hydration Index of Different Solutions

Sponsor

University of Memphis

Enrollment

30 participants

Start Date

Feb 23, 2026

Study Type

INTERVENTIONAL

Conditions

Hydration

Summary

In this study, the impact of two electrolyte hydration stick products (Hydramin containing an electrolyte/amino acid formulation and an identical electrolyte product with the amino-acids replaced with carbohydrate, dextrose) dissolved in 1 liter of water will be assessed and compared to a control (1 liter Smart Water). It is hypothesized that the addition of amino acids and glycine should improve the BHI above water alone and perform comparably to the carbohydrate rich solution. This study will focus on general population (not athletes) and follow very similar approaches used in previous studies within the Center for Nutraceutical and Dietary Supplements Research, with the addition of blood glucose testing and body water measurements. Hydration will be assessed via fluid balance (the difference between the amount of water consumed and passed as urine) and calculations of beverage hydration index (the relative amount of urine passed after consumption of a drink compared to water)as well as time in positive fluid balance, and specific gravity, and sodium and potassium in urine. Blood glucose before and following consumption using finger pricks and a glucometer will also be assessed.

Eligibility

Min Age: 18 Years

Inclusion Criteria18

Be age 18 years or older
male or female
have a body mass index (BMI)between 18.5-35 kg/m2 (not morbidly obese)
Be engaged in moderate physical activity, defined as ≤5 hours/week of aerobic exercise
Not have a history or presence of a clinically relevant (that required or requires treatment) cardiac, renal, hepatic, endocrine (including diabetes mellitus), pulmonary, biliary, gastrointestinal, pancreatic, or neurologic disorder (reviewed by Nurse practitioner)
Not have other conditions that are likely to alter fluid balance or be negatively affected by changing electrolyte levels/hydration status (as determined by Nurse practitioner)
Not be consuming any medication which may alter fluid retention/electrolyte levels such as SSRIs (Selective Serotonin Reuptake Inhibitors), sodium-glucose co-transporter 2 (SGLT2) inhibitor (for type 2 diabetes), laxatives, diuretics, Apremilast, chemotherapy, or lithium. (Medications will be reviewed by Nurse practitioner)
Not consume nutritional supplements, performance enhancing drugs, and/or non-steroidal anti-inflammatory drugs within 7 days of study visits excluding screening.
Follow the lifestyle and dietary restrictions before study visits (excluding screening/consenting visit) including before each visit avoiding strenuous activity for 24 hours prior, refrain from caffeine for 12 hours and alcohol for 24 hours, consume the standardized diet and maintain similar activity levels for 24 hours prior, consume 2.5 liters for men or 2.0 liters for women day prior, and fast (water only) of at least 10 hours prior.
Not have a sensitivity or be allergic to any components of the study interventions (water, calcium chloride, magnesium chloride, potassium bicarbonate, magnesium, sodium, chloride, potassium, vitamin C, dextrose, AminoAbsorb (L-alanine, L-glutamine, glycine).
Not be a tobacco user
Not be following a specialized dietary pattern that may alter findings (e.g., low carbohydrate/ketogenic diet, carnivore diet, intermittent fasting etc.)
Arrive to lab for visits euhydrated (USG 1.005-1.020)
Have the ability and willingness to fast (consume water/treatments only) for 15 hours (10 hours prior to lab visits not including screening)
Not be enrolled in another clinical study within 30 days of the first study visit
Be without active infection or illness of any kind
Not be pregnant or breastfeeding
Not have surgery in the previous 4 months

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Interventions

DIETARY_SUPPLEMENTHyddramin hydration solution

4 sticks of electrolyte and amino acid powder dissolved in 1 L Smart Water. Ingredients: Sodium, Chloride, Potassium, Magnesium, Vitamin C, AminoAbsorb (L-glutamine, L-Alanine, Glycine)

DIETARY_SUPPLEMENTCarbohydrate and Electrolyte hydration solution

4 sticks of electrolyte and carbohydrate powder dissolved in 1 L Smart Water. Ingredients: Sodium, Chloride, Potassium, Magnesium, Vitamin C, Dextrose

DIETARY_SUPPLEMENTWater

1 L Smart Water