Effect of Hypothermia on BIS and PSI Correlation During Cardiopulmonary Bypass
Effect of Hypothermia on the Correlation Between Bispectral Index (BIS) and Patient State Index (PSI) During Cardiopulmonary Bypass
Sakarya University
60 participants
May 1, 2026
OBSERVATIONAL
Conditions
Summary
The goal of this observational study is to evaluate whether hypothermia affects the relationship between electroencephalography-derived indices during cardiac surgery in adult patients undergoing cardiopulmonary bypass. The main questions it aims to answer are: Does the correlation between Bispectral Index (BIS) and Patient State Index (PSI) change between normothermic and hypothermic phases during cardiopulmonary bypass? How do BIS and PSI values change in response to decreasing body temperature? Participants will: Undergo standard general anesthesia for elective on-pump coronary artery bypass surgery Be monitored simultaneously with BIS and PSI devices during surgery Have data recorded at predefined temperature-based time points during cardiopulmonary bypass
Eligibility
Inclusion Criteria4
- Age ≥18 years
- Elective on-pump Coronary Artery Bypass Grafting (CABG) surgery
- Planned use of general anesthesia
- Written informed consent
Exclusion Criteria5
- Preexisting neurological disease
- Use of medications affecting Electroencephalography (e.g., antiepileptics)
- Severe hepatic dysfunction
- Emergency surgery
- Inadequate signal quality for anesthesia depth monitoring
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Interventions
This observational study does not involve any experimental intervention. All participants will receive standard anesthesia and surgical care according to institutional protocols. The study focuses on simultaneous intraoperative monitoring using Bispectral Index (BIS) and Patient State Index (PSI) devices. Sensors for both monitors will be applied prior to induction of anesthesia, and values will be recorded at predefined time points during normothermic, hypothermic, and rewarming phases of cardiopulmonary bypass. No changes will be made to routine clinical management, and all treatments will be determined by the attending anesthesiologist.
Locations(1)
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NCT07508579